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Table 3 Hemodynamic variables in the whole population depending on whether the achieved mean arterial pressure after introduction of norepinephrine (or increase in its dose) was either inferior (n = 53) or superior (n = 52) to the median value (75 mm Hg)

From: Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

 

Achieved MAP <75 mm Hg

Achieved MAP ≥75 mm Hg

 

Before NE

(introduction/increase)

After NE

(introduction/increase)

Before NE

(introduction/increase)

After NE

(introduction/increase)

Heart rate, beats/min

103 ± 20

101 ± 20

93 ± 21

94 ± 20

MAP, mm Hg

51 ± 7

68 ± 4a

57 ± 7

83 ± 6a

DAP, mm Hg

36 ± 7

48 ± 7a

40 ± 6

56 ± 8a

CI, L/min/m2

3.2 ± 1.1

3.6 ± 1.1a

3.2 ± 0.9

3.7 ± 1.1a

SVI, ml/m2

32 ± 12

37 ± 13a

38 ± 12

42 ± 14a

GEDVI, ml/m2

698 ± 139

752 ± 161a

691 ± 157

743 ± 181a

CFI, per min

4.7 ± 1.8

4.9 ± 1.7a

4.8 ± 1.3

5.1 ± 1.5a

SVRI, dynes/sec/cm5/m2

1,435 ± 535

1,704 ± 592a

1,497 ± 542

1,937 ± 582a

  1. CFI, cardiac function index; CI, cardiac index; DAP, diastolic arterial pressure; GEDVI, global end-diastolic volume index; HR, heart rate; MAP, mean arterial pressure; NE, norepinephrine; SVI, stroke volume index; SVRI, index of systemic vascular resistance.
  2. aP < 0.05 vs. before norepinephrine.