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Table 3 Hemodynamic variables in the whole population depending on whether the achieved mean arterial pressure after introduction of norepinephrine (or increase in its dose) was either inferior (n = 53) or superior (n = 52) to the median value (75 mm Hg)

From: Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension

  Achieved MAP <75 mm Hg Achieved MAP ≥75 mm Hg
  Before NE
(introduction/increase)
After NE
(introduction/increase)
Before NE
(introduction/increase)
After NE
(introduction/increase)
Heart rate, beats/min 103 ± 20 101 ± 20 93 ± 21 94 ± 20
MAP, mm Hg 51 ± 7 68 ± 4a 57 ± 7 83 ± 6a
DAP, mm Hg 36 ± 7 48 ± 7a 40 ± 6 56 ± 8a
CI, L/min/m2 3.2 ± 1.1 3.6 ± 1.1a 3.2 ± 0.9 3.7 ± 1.1a
SVI, ml/m2 32 ± 12 37 ± 13a 38 ± 12 42 ± 14a
GEDVI, ml/m2 698 ± 139 752 ± 161a 691 ± 157 743 ± 181a
CFI, per min 4.7 ± 1.8 4.9 ± 1.7a 4.8 ± 1.3 5.1 ± 1.5a
SVRI, dynes/sec/cm5/m2 1,435 ± 535 1,704 ± 592a 1,497 ± 542 1,937 ± 582a
  1. CFI, cardiac function index; CI, cardiac index; DAP, diastolic arterial pressure; GEDVI, global end-diastolic volume index; HR, heart rate; MAP, mean arterial pressure; NE, norepinephrine; SVI, stroke volume index; SVRI, index of systemic vascular resistance.
  2. aP < 0.05 vs. before norepinephrine.