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Table 3 The predictive value of estimated dead-space fraction at day 1 and day 3 of ALI/ARDS in the ARDS-network validation cohort, outcome hospital mortality

From: Bedside quantification of dead-space fraction using routine clinical data in patients with acute lung injury: secondary analysis of two prospective trials

Mortality Odds ratio 95% CI
Day 1    
(Per 0.05 increment of dead space fraction)    
Univariate analysis
VdVt 1.11 1.06 1.16
Multivariate analysis
Base Model (Shock + APACHE III predicted mortality), n = 1616 1.09 1.04 1.14
Base model + PaO2/FiO2, n = 1,610 1.07 1.03 1.13
Base model + OI, n = 1,492 1.08 1.03 1.14
Base model + PaO2/FiO2 + PEEP, n = 1,610 1.08 1.03 1.14
Base model + PaO2/FiO2 + PEEP, n = 1,492 1.09 1.04 1.15
Base model + Vt, n = 1,616 1.10 1.06 1.16
Day 3    
(Per 0.05 increment of dead space fraction)    
Univariate analysis
VdVt 1.18 1.12 1.24
Multivariate analysis
Base Model (Shock + APACHE III predicted mortality), n = 1,369 1.14 1.09 1.21
Base model + PaO2/FiO2, n = 1,369 1.12 1.06 1.18
Base model + OI, n = 1,241 1.10 1.04 1.17
Base model + PaO2/FiO2 + PEEP, n = 1,367 1.10 1.04 1.16
Base model + PaO2/FiO2 + PEEP, n = 1,241 1.10 1.04 1.17
Base model + Vt, n = 1,283 1.16 1.10 1.23
  1. ALI, acute lung injury; APACHE, acute physiology and chronic health evaluation; ARDS, acute respiratory distress syndrome; CI, confidence interval; FiO2, fraction of inspired oxygen; PaO2, partial pressureof arterial pressure; PEEP, positive end-expiratory pressure; OI, oxygenation index; VdVt, dead space fraction; Vt, tidal volume.