Cerebral microcirculation is impaired during sepsis: an experimental study

Table 2 Evolution in cerebral microcirculation over time in the septic (n = 10) and the sham (n = 5) animals

		Baseline	6 hours	12 hours	18 hours^#	ANOVA
						Time ( P )	Groups ( P )
TVD	Sepsis	6.1 ± 0.8	5.4 ± 0.5	5.7 ± 0.8	5.4 ± 0.6	0.15	0.61
	Sham	5.8 ± 0.8	5.9 ± 0.7	5.6 ± 0.8	5.8 ± 0.6	0.65
TPVD	Sepsis	5.9 ± 0.9	5.1 ± 0.5	5.1 ± 0.6	4.8 ± 0.7^a	0.009	0.14
	Sham	5.7 ± 0.7	5.8 ± 0.7	5.5 ± 0.7	5.5 ± 0.5	0.76
NPC	Sepsis	22.7 ± 2.8	18.8 ± 3.2 *	18.7 ± 5.9 *	17.5 ± 5.2 *^a	0.048	< 0.001
	Sham	25.1 ± 0.9	24.7 ± 2.3	23.8 ± 3.3	25.8 ± 0.8	0.42
MFI	Sepsis	2.9 ± 0.1	2.9 ± 0.1	2.9 ± 0.1	2.7 ± 0.3	0.21	0.87
	Sham	2.9 ± 0.1	2.9 ± 0.1	2.9 ± 0.1	2.8 ± 0.2	0.33
PSPV - HI	Sepsis	0.11 ± 0.06 *	0.26 ± 0.15 *^a	0.23 ± 0.11 *	0.32 ± 0.13 *^a	0.002	< 0.001
	Sham	0.04 ± 0.01	0.03 ± 0.01	0.03 ± 0.02	0.06 ± 0.04	0.25
MFI - HI	Sepsis	0.13 ± 0.07	0.18 ± 0.13	0.23 ± 0.14 *^a	0.25 ± 0.14 *^a	0.003	0.002
	Sham	0.07 ± 0.06	0.18 ± 0.09	0.08 ± 0.05	0.13 ± 0.07	0.19

Data are presented as mean ± SD.
^# Shock onset for septic group.
Significant at 5% vs. baseline (^a), vs 6 hours (^b) or vs 12 hours (^c). Significant at 5% vs. sham (*).
TVD, total vessel density; TPVD, total perfused vessel density; PSPV, proportion of small perfused vessels; FCD, functional capillary density; NPC, number of perfused capillaries; MFI, mean flow index; HI, heterogeneity index; (P) = P- value.
No interference between time and groups was found for all the studied variables in ANOVA analysis. Significant at 5% vs. baseline (^a), or vs. sham (*) in post-hoc Bonferroni correction.

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