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Table 2 Evolution in cerebral microcirculation over time in the septic (n = 10) and the sham (n = 5) animals

From: Cerebral microcirculation is impaired during sepsis: an experimental study

   Baseline 6 hours 12 hours 18 hours# ANOVA
       Time ( P ) Groups ( P )
TVD Sepsis 6.1 ± 0.8 5.4 ± 0.5 5.7 ± 0.8 5.4 ± 0.6 0.15 0.61
  Sham 5.8 ± 0.8 5.9 ± 0.7 5.6 ± 0.8 5.8 ± 0.6 0.65  
TPVD Sepsis 5.9 ± 0.9 5.1 ± 0.5 5.1 ± 0.6 4.8 ± 0.7a 0.009 0.14
  Sham 5.7 ± 0.7 5.8 ± 0.7 5.5 ± 0.7 5.5 ± 0.5 0.76  
NPC Sepsis 22.7 ± 2.8 18.8 ± 3.2 * 18.7 ± 5.9 * 17.5 ± 5.2 *a 0.048 < 0.001
  Sham 25.1 ± 0.9 24.7 ± 2.3 23.8 ± 3.3 25.8 ± 0.8 0.42  
MFI Sepsis 2.9 ± 0.1 2.9 ± 0.1 2.9 ± 0.1 2.7 ± 0.3 0.21 0.87
  Sham 2.9 ± 0.1 2.9 ± 0.1 2.9 ± 0.1 2.8 ± 0.2 0.33  
PSPV - HI Sepsis 0.11 ± 0.06 * 0.26 ± 0.15 *a 0.23 ± 0.11 * 0.32 ± 0.13 *a 0.002 < 0.001
  Sham 0.04 ± 0.01 0.03 ± 0.01 0.03 ± 0.02 0.06 ± 0.04 0.25  
MFI - HI Sepsis 0.13 ± 0.07 0.18 ± 0.13 0.23 ± 0.14 *a 0.25 ± 0.14 *a 0.003 0.002
  Sham 0.07 ± 0.06 0.18 ± 0.09 0.08 ± 0.05 0.13 ± 0.07 0.19  
  1. Data are presented as mean ± SD.
  2. # Shock onset for septic group.
  3. Significant at 5% vs. baseline (a), vs 6 hours (b) or vs 12 hours (c). Significant at 5% vs. sham (*).
  4. TVD, total vessel density; TPVD, total perfused vessel density; PSPV, proportion of small perfused vessels; FCD, functional capillary density; NPC, number of perfused capillaries; MFI, mean flow index; HI, heterogeneity index; (P) = P- value.
  5. No interference between time and groups was found for all the studied variables in ANOVA analysis. Significant at 5% vs. baseline (a), or vs. sham (*) in post-hoc Bonferroni correction.