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Table 1 Evolution of systemic hemodynamics and acid-base variables over time in the septic (n = 10) and the sham (n = 5) animals

From: Cerebral microcirculation is impaired during sepsis: an experimental study

   Baseline 6 hours 12 hours 18 hours# ANOVA
       Time ( P ) Groups ( P )
Temperature, °C Sepsis 39.5 ± 0.5 39.9 ± 0.8 40.2 ± 1.1a,b 41.2 ± 0.8a,b,c * 0.0002 0.01
  Sham 39.6 ± 0.3 39.4 ± 0.5 39.7 ± 0.7 40.4 ± 0.5 0.65  
HR, beats/min Sepsis 116 ± 27 137 ± 22a 138 ± 14a 140 ± 15a 0.05 0.38
  Sham 108 ± 15 132 ± 13 132 ± 14 133 ± 8a 0.04  
Cardiac Index, L/min.m 2 Sepsis 4.5 ± 0.5 7.3 ± 1.3a * 6.9 ± 1.5a * 5.6 ± 1.3 < 0.0001 < 0.0001
  Sham 4.5 ± 0.6 5.3 ± 1.0 5.2 ± 1.0 5.0 ± 0.4 0.21  
MAP, mmHg Sepsis 106 ± 11 101 ± 11 84 ± 10a * 56 ± 6a,b * < 0.0001 0.0002
  Sham 112 ± 11 105 ± 9 107 ± 10 100 ± 4 0.32  
MPAP, mmHg Sepsis 15 ± 4 14 ± 2 19 ± 4a,b 20 ± 4a,b < 0.0001 0.06
  Sham 16 ± 1 15 ± 3 16 ± 3 17 ± 5 0.86  
SVRI, dynes.sec.cm -5 Sepsis 1853 ± 211 1120 ± 248a 960 ± 211a * 777 ± 176a,b * < 0.0001 < 0.0001
  Sham 1907 ± 253 1540 ± 292 1597 ± 273 1691 ± 138 0.1  
PF ratio Sepsis 302 ± 110 326 ± 113 283 ± 96 * 197 ± 91b * 0.01 < 0.0001
  Sham 392 ± 68 407 ± 40 377 ± 24 379 ± 29 0.69  
PaCO2, mmHg Sepsis 41 ± 3 39 ± 2 41 ± 4 46 ± 9b 0.009 0.11
  Sham 37 ± 3 39 ± 3 39 ± 4 42 ± 4 0.09  
TPC, mL/mmHg Sepsis 18 ± 2 19 ± 4 15 ± 4 12 ± 3a,b 0.0002 0.23
  Sham 18 ± 3 18 ± 1 17 ± 2 15 ± 3 0.22  
Urine output, mL/hr Sepsis 96 ± 36 105 ± 100 99 ± 85 127 ± 65 0.53 0.053
  Sham 79 ± 25 128 ± 45 155 ± 99 95 ± 35 0.48  
Fluid amount, mL Sepsis 314 ± 110 1635 ± 596a * 1705 ± 497a * 2210 ± 854a,b,c * < 0.0001 < 0.0001
  Sham 218 ± 65 265 ± 93 310 ± 74 278 ± 61 0.81  
Hemoglobin, g/dL Sepsis 10.7 ± 1.1 10.9 ± 1.6 11.1 ± 1.2 11.6 ± 1.6 0.56 0.66
  Sham 10.5 ± 0.7 10.5 ± 0.8 11.3 ± 0.7 11.4 ± 0.7 0.49  
Lactate (mEq/L) Sepsis 0.9 ± 0.3 1.3 ± 0.5 1.7 ± 0.7a * 4.0 ± 1.2a,b,c * < 0.0001 < 0.0001
  Sham 0.7 ± 0.2 0.6 ± 0.3 0.7 ± 0.2 0.8 ± 0.4 0.71  
  1. Data are presented as mean ± SD.
  2. # Shock onset for septic group.
  3. °C, Celsius degrees; HR, heart rate; CI, cardiac index; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; SVRI, systemic vascular resistance index; PF, PaO2/FiO2; TPC, thoraco-pulmonary compliance.
  4. No interference between time and groups was found for all the studied variables in ANOVA analysis. Significant at 5% vs. baseline (a), vs 6 hours (b) or vs 12 hours (c) or significant at 5% vs. sham (*) in post-hoc Bonferroni correction.