Table 1 Evolution of systemic hemodynamics and acid-base variables over time in the septic (n = 10) and the sham (n = 5) animals

Temperature, °C

Sepsis

39.5 ± 0.5

39.9 ± 0.8

40.2 ± 1.1^a,b

41.2 ± 0.8^a,b,c *

0.0002

0.01

Sham

39.6 ± 0.3

39.4 ± 0.5

39.7 ± 0.7

40.4 ± 0.5

0.65

HR, beats/min

Sepsis

116 ± 27

137 ± 22^a

138 ± 14^a

140 ± 15^a

0.05

0.38

Sham

108 ± 15

132 ± 13

132 ± 14

133 ± 8^a

0.04

Cardiac Index, L/min.m ²

Sepsis

4.5 ± 0.5

7.3 ± 1.3^a *

6.9 ± 1.5^a *

5.6 ± 1.3

< 0.0001

< 0.0001

Sham

4.5 ± 0.6

5.3 ± 1.0

5.2 ± 1.0

5.0 ± 0.4

0.21

MAP, mmHg

Sepsis

106 ± 11

101 ± 11

84 ± 10^a *

56 ± 6^a,b *

< 0.0001

0.0002

Sham

112 ± 11

105 ± 9

107 ± 10

100 ± 4

0.32

MPAP, mmHg

Sepsis

15 ± 4

14 ± 2

19 ± 4^a,b

20 ± 4^a,b

< 0.0001

0.06

Sham

16 ± 1

15 ± 3

16 ± 3

17 ± 5

0.86

SVRI, dynes.sec.cm ^-5

Sepsis

1853 ± 211

1120 ± 248^a

960 ± 211^a *

777 ± 176^a,b *

< 0.0001

< 0.0001

Sham

1907 ± 253

1540 ± 292

1597 ± 273

1691 ± 138

0.1

PF ratio

Sepsis

302 ± 110

326 ± 113

283 ± 96 *

197 ± 91^b *

0.01

< 0.0001

Sham

392 ± 68

407 ± 40

377 ± 24

379 ± 29

0.69

PaCO2, mmHg

Sepsis

41 ± 3

39 ± 2

41 ± 4

46 ± 9^b

0.009

0.11

Sham

37 ± 3

39 ± 3

39 ± 4

42 ± 4

0.09

TPC, mL/mmHg

Sepsis

18 ± 2

19 ± 4

15 ± 4

12 ± 3^a,b

0.0002

0.23

Sham

18 ± 3

18 ± 1

17 ± 2

15 ± 3

0.22

Urine output, mL/hr

Sepsis

96 ± 36

105 ± 100

99 ± 85

127 ± 65

0.53

0.053

Sham

79 ± 25

128 ± 45

155 ± 99

95 ± 35

0.48

Fluid amount, mL

Sepsis

314 ± 110

1635 ± 596^a *

1705 ± 497^a *

2210 ± 854^a,b,c *

< 0.0001

< 0.0001

Sham

218 ± 65

265 ± 93

310 ± 74

278 ± 61

0.81

Hemoglobin, g/dL

Sepsis

10.7 ± 1.1

10.9 ± 1.6

11.1 ± 1.2

11.6 ± 1.6

0.56

0.66

Sham

10.5 ± 0.7

10.5 ± 0.8

11.3 ± 0.7

11.4 ± 0.7

0.49

Lactate (mEq/L)

Sepsis

0.9 ± 0.3

1.3 ± 0.5

1.7 ± 0.7^a *

4.0 ± 1.2^a,b,c *

< 0.0001

< 0.0001

Sham

0.7 ± 0.2

0.6 ± 0.3

0.7 ± 0.2

0.8 ± 0.4

0.71