From: APCAP - activated protein C in acute pancreatitis: a double-blind randomized human pilot trial
N | APC | Placebo | Difference in means between the study groups (95% CI) | ||
---|---|---|---|---|---|
Delta SOFA score | 16 | 1.8 (4.3) | 16 | -0.6 (4.1) | 2.3 (-0.7 to 5.2) |
Delta-non-hepatic SOFA | 16 | 1.9 (4.1) | 16 | -0.2 (3.9) | 2.1 (-0.8 to 4.9) |
Ventilator free days | 16 | 10.4 (9.4) | 16 | 10.4 (11.5) | 0 (-7.4 to 7.4) |
Renal replacement therapy-free days | 16 | 52.7 (12.7) | 16 | 55.3 (9.3) | -2.6 (-10.5 to 5.3) |
Vasopressor-free days | 16 | 52.8 (7.1) | 16 | 55.1 (6.0) | -2.6 (-5.9 to 2.3) |
Alive outside hospital - days | 16 | 17.1 (32.5) | 16 | 34.4 (13.0) | -17.4 (-0.1 to -34.9) |
Delta modified CT score | 11 | 0.5 (2.0) | 11 | 0.5 (1.8) | 0 (-1.6 to 1.6) |
Delta serum bilirubin, total (μmol/L) | 16 | 18 (46.4) | 16 | -10 (17.0) | 28 (3.6 to 53.1) * |
Delta serum bilirubin, conjugated (μmol/L) | 13 | 14 (31.9) | 12 | -11 (11.1) | 25 (5.6 to 44.4) * |
Delta serum creatinine (μmol/L) | 16 | -37 (84) | 16 | 13 (86) | -50 (-110 to 10) |
Delta platelet count (× 109/L) | 16 | 32 (52) | 16 | 35 (55) | -3 (-40 to 34) |
Delta plasma hemoglobin mg/L | 13 | -226 (499.5) | 16 | -65 (83.2) | -161 (-413 to 92.0) |
Delta serum pre-albumin mg/L | 13 | -50 (49.7) | 12 | -69 (55.2) | 19 (-23.0 to 61.0) |