|
Variables
|
Control
|
Surfactant
|
P value
|
|---|
| |
(n = 10)
|
(n = 10)
| |
|
Male/female
|
9/1
|
8/2
|
NS
|
|
Age (years)
|
59 ± 16
|
62 ± 12
|
NS
|
|
SAPS II
|
40 ± 10
|
41 ± 10
|
NS
|
|
LISS
|
2.3 ± 0.4
|
2.6 ± 0.5
|
NS
|
|
Septic shock (%)
|
80%
|
70%
|
NS
|
|
Survival (%)
|
70%
|
70%
|
NS
|
|
Cause of ALI/ARDS
| | | |
|
Bronchopneumonia
|
4
|
6
| |
|
Aspiration pneumonia
|
1
|
1
|
NS
|
|
Lung contusion
|
2
|
0
| |
|
Sepsis
|
3
|
3
| |
|
PaCO2 (mmHg)
|
38.4 ± 8.2
|
37.9 ± 7
|
NS
|
|
PaO2/FiO2 (mmHg)
|
200 ± 63
|
201 ± 64
|
NS
|
|
TV/kg (ml)
|
5.7 ± 0.8
|
6 ± 0.9
|
NS
|
|
RR (breaths/min)
|
23 ± 4
|
20 ± 6
|
NS
|
|
Ppeak (cmH2O)
|
32 ± 5
|
32 ± 6
|
NS
|
|
Pplat (cmH2O)
|
23 ± 4
|
23 ± 5
|
NS
|
|
PEEP (cmH2O)
|
9.7 ± 0.9
|
9.4 ± 1
|
NS
|
|
Crs (ml.cmH2O-1)
|
38 ± 12
|
41 ± 23
|
NS
|
|
HR (beats/min)
|
110 ± 23
|
88 ± 24
|
NS
|
|
MAP (mmHg)
|
86 ± 15
|
87 ± 20
|
NS
|
- ALI, acute lung injury; ARDS, acute respiratory distress syndrome; Crs, compliance of respiratory system; FiO2, fraction of inspired oxygen; HR, heart rate; LISS, lung injury severity score; MAP, mean arterial pressure; NS, not significant; PaCO2, partial pressure of arterial carbon dioxide; PaO2, partial pressure of arterial oxygen; Ppeak, peak airway pressure; PEEP, positive end-expiratory pressure; Pplat, plateau airway pressure; RR, respiratory rate; SAPS II, simplified acute physiology score II; Surfactant, porcine-derived lung surfactant; TV, tidal volume.
- Data are expressed as mean ± standard deviation.
