Volumes of gas and tissue at baseline before HL-10 instillation (upper part of the figure) and changes in volume of gas and tissue between H39 (within three hours following the third bolus of HL-10) and baseline (lower part of the figure). Results shown in right upper and middle lobes (RUL), left upper lobe (LUL), right lower lobe (RLL) and left lower lobe (LLL) in patients with acute lung injury/acute respiratory distress syndrome instilled with 200 mg/kg of HL-10. Comparisons were performed by Friedman repeated measures analysis of variance on ranks followed by a Tukey test. P values above the horizontal brackets indicate significant difference between RUL, LUL, RLL and LLL using Friedman repeated measures analysis of variance.* P < 0.05 versus RUL, § P < 0.05 versus LUL.