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Table 5 Outcome effect estimates

From: Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective

Outcome

N

OR (95%CrI)

P(%)

Ï„ (95%CrI)

β (95%CrI)

Pβ(%)

Mortality

      

High dose

5

0.912 (0.313 to 1.253)

42.0

1.00 (0.42 to 1.89)

  

   High dose excluding Schumer [31]

4

1.406 (0.727 to 2.614)

89.3

0.25 (0.01 to 1.40)

  

Low dose

9

0.796 (0.396 to 1.386)

20.4

0.65 (0.23 to 1.44)

  

   Low dose excluding CSG [32]

8

0.706 (0.371 to 1.096)

5.8

0.39 (0.04 to 1.15)

  

Corticotrophin responders*

4

0.882 (0.285 to 2.073)

36.4

0.49 (0.02 to 1.78)

  

Corticotrophin non-responders*

4

0.831 (0.334 to 1.971)

28.0

0.43 (0.02 to 1.69)

  

Shock-reversal

      

High dose

2

1.078 (0.227 to 6.311)

54.9

1.39 (0.06 to 1.93)

  

Low dose

7

1.999 (1.069 to 4.55)

98.2

0.57 (0.04 to 1.62)

  

Corticotrophin responders*

3

1.830 (0.499 to 7.845)

86.7

0.87 (0.05 to -1.92)

  

Corticotrophin non-responders*

3

1.845 (0.637 to 7.267)

91.9

0.55 (0.02 to 1.86)

  

Meta-regression (log odds mortality)

      

Average age

High dose

4

0.777 (0.285 to 2.426)

27.3

0.72 (0.04 to 1.87)

0.60 (-0.23 to 1.51)

94.52

 

Excl Schumer [31]

3

1.390 (0.399 to 4.872)

77.0

0.66 (0.03 to 1.90)

0.10 (-1.57 to 1.74)

58.05

 

Low dose

6

0.658 (0.334 to 1.223)

7.6

0.36 (0.02 to 1.51)

0.05 (-0.10 to 0.18)

80.53

Underlying risk

High dose

5

0.943 (0.292 to 3.049)

45.4

1.14 (0.46 to 1.49)

0.23 (-1.71 to 2.58)

60.98

 

Excl Schumer [31]

4

1.372 (0.596 to 3.249)

82.9

0.38 (0.01 to 1.74)

-0.09 (-1.31 to 1.42)

41.47

 

Low dose

9

0.752 (0.389 to 1.291)

14.5

0.57 (0.17 to 1.37)

-0.49 (-1.14 to 0.27)

7.80

 

Excl CSG [32]

8

0.676 (0.347 to 1.076)

4.9

0.40 (0.03 to 1.23)

-0.28 (-0.88 to 0.50)

19.08

Odds of the following complications (corticosteroids versus control)

      

Superinfection

High dose

4

1.127 (0.364 to 3.924)

62.2

0.55 (0.02 to 2.85)

  
 

Low dose

6

0.955 (0.388 to 1.749)

43.6

0.46 (0.03 to 1.62)

  

GI bleeding

High dose

3

0.824 (0.167 to 3.186)

37.3

0.74 (0.03 to 1.90)

  
 

Low dose

5

1.103 (0.379 to 3.031)

59.6

0.58 (0.02 to 1.84)

  

Hyperglycemia

High dose

3

1.012 (0.244 to 4.266)

50.8

0.64 (0.03 to 1.88)

  
 

Low dose

3

1.430 (0.155 to 3.985)

57.4

0.87 (0.05 to 1.93)

  
  1. *all studies were low dose; CI, confidence interval; CSG, Cooperative Study Group; GI, gastro-intestinal; N, number of studies reporting data for that endpoint; NA, not applicable; OR, odds ratio. Excl Sch = Excluding Schumer [31]; Excl CSG = Excluding CSG [32]