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Table 5 Outcome effect estimates

From: Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective

Outcome N OR (95%CrI) P(%) τ (95%CrI) β (95%CrI) Pβ(%)
Mortality       
High dose 5 0.912 (0.313 to 1.253) 42.0 1.00 (0.42 to 1.89)   
   High dose excluding Schumer [31] 4 1.406 (0.727 to 2.614) 89.3 0.25 (0.01 to 1.40)   
Low dose 9 0.796 (0.396 to 1.386) 20.4 0.65 (0.23 to 1.44)   
   Low dose excluding CSG [32] 8 0.706 (0.371 to 1.096) 5.8 0.39 (0.04 to 1.15)   
Corticotrophin responders* 4 0.882 (0.285 to 2.073) 36.4 0.49 (0.02 to 1.78)   
Corticotrophin non-responders* 4 0.831 (0.334 to 1.971) 28.0 0.43 (0.02 to 1.69)   
Shock-reversal       
High dose 2 1.078 (0.227 to 6.311) 54.9 1.39 (0.06 to 1.93)   
Low dose 7 1.999 (1.069 to 4.55) 98.2 0.57 (0.04 to 1.62)   
Corticotrophin responders* 3 1.830 (0.499 to 7.845) 86.7 0.87 (0.05 to -1.92)   
Corticotrophin non-responders* 3 1.845 (0.637 to 7.267) 91.9 0.55 (0.02 to 1.86)   
Meta-regression (log odds mortality)       
Average age High dose 4 0.777 (0.285 to 2.426) 27.3 0.72 (0.04 to 1.87) 0.60 (-0.23 to 1.51) 94.52
  Excl Schumer [31] 3 1.390 (0.399 to 4.872) 77.0 0.66 (0.03 to 1.90) 0.10 (-1.57 to 1.74) 58.05
  Low dose 6 0.658 (0.334 to 1.223) 7.6 0.36 (0.02 to 1.51) 0.05 (-0.10 to 0.18) 80.53
Underlying risk High dose 5 0.943 (0.292 to 3.049) 45.4 1.14 (0.46 to 1.49) 0.23 (-1.71 to 2.58) 60.98
  Excl Schumer [31] 4 1.372 (0.596 to 3.249) 82.9 0.38 (0.01 to 1.74) -0.09 (-1.31 to 1.42) 41.47
  Low dose 9 0.752 (0.389 to 1.291) 14.5 0.57 (0.17 to 1.37) -0.49 (-1.14 to 0.27) 7.80
  Excl CSG [32] 8 0.676 (0.347 to 1.076) 4.9 0.40 (0.03 to 1.23) -0.28 (-0.88 to 0.50) 19.08
Odds of the following complications (corticosteroids versus control)       
Superinfection High dose 4 1.127 (0.364 to 3.924) 62.2 0.55 (0.02 to 2.85)   
  Low dose 6 0.955 (0.388 to 1.749) 43.6 0.46 (0.03 to 1.62)   
GI bleeding High dose 3 0.824 (0.167 to 3.186) 37.3 0.74 (0.03 to 1.90)   
  Low dose 5 1.103 (0.379 to 3.031) 59.6 0.58 (0.02 to 1.84)   
Hyperglycemia High dose 3 1.012 (0.244 to 4.266) 50.8 0.64 (0.03 to 1.88)   
  Low dose 3 1.430 (0.155 to 3.985) 57.4 0.87 (0.05 to 1.93)   
  1. *all studies were low dose; CI, confidence interval; CSG, Cooperative Study Group; GI, gastro-intestinal; N, number of studies reporting data for that endpoint; NA, not applicable; OR, odds ratio. Excl Sch = Excluding Schumer [31]; Excl CSG = Excluding CSG [32]