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Table 3 Circulating blood leukocyte phenotyping in septic shock patients

From: Upregulation of the pro-apoptotic genes BID and FAS in septic shock patients

  Healthy controls Septic shock patients
   Days 1 to 2 Days 3 to 5
Leukocytes 5658 (4,954 to 6,146) 14,673 (9,562 to 18,446) 15,390* (10,097 to 25,235)
Lymphocytes 1549 (1,295 to 1,831) 701* (432 to 1,531) 1,110 (634 to 1,482)
T cells 1090 (902 to 1,470) 421* (209 to 547) 529 (335 to 1,031)
CD4+ T lymphocytes 890 (569 to 1,141) 220* (115 to 354) 479 (218 to 827)
CD8+ T lymphocytes 320 (228 to 349) 155* (36 to 207) 158 (70 to 304)
  1. Results expressed as the median (interquartile range, Q1 to Q3) number of cells/μl. Blood samples were obtained from 13 septic shock patients at days 1 to 2 and at days 3 to 5 after diagnosis of shock. Circulating leukocyte immunophenotyping was systematically performed by flow cytometry. The following leukocyte subsets were analyzed: total number of leukocytes, total number of lymphocytes, T cells (CD45+CD3+), and CD4+ (CD45+CD4+CD3+) and CD8+ (CD45+CD8+CD3+) T-lymphocyte subpopulations. Comparison versus healthy volunteers values (mean) performed using the Mann-Whitney U test with correction for the number of tests performed: *P < 0.025.
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Critical Care

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