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Table 4 Different models of logistic regression to predict sepsis diagnosis on admission * (n = 74 patients)

From: Proven infection-related sepsis induces a differential stress response early after ICU admission

 

AUC (95% CI)

OR (95% CI)

P-value

Model 1 (M1)

   

   ACTH ≤ 233 nM/L

0.875 (0.774 to 0.942)

9.192 (2.466 to 34.265)

0.001

   Cortisol baseline ≥ 450 nM/L

 

4.279 (1.007 to 18.181)

0.049

   Sepsis score >7

 

5.371 (1.567 to 18.404)

0.007

Model 2 (M2)

   

   ACTH ≤ 233 nM/L

0.903 (0.808 to 0.960)

21.16 (4.252 to 105.307)

0.0002

   Cortisol baseline ≥ 450 nM/L

 

8.81 (1.616 to 48.037)

0.012

   Procalcitonin (PCT) >2 ng/mL

 

28.558 (4.393 to 185.636)

0.0004

Model 3 (M3)

   

   ACTH ≤ 233 nM/L

0.805 (0.693 to 0.890)

9.125 (2.667 to 31.218)

0.0004

   Cortisol baseline ≥ 450 nM/L

 

7.457 (1.89 to 29.426)

0.004

Model 4 (M4)

   

   Procalcitonin (PCT) >2 ng/mL

0.726 (0.607 to 0.826)

16.889 (3.523 to 80.959)

0.0004

Model 5 (M5)

   

   Sepsis score >7

0.727 (0.607 to 0.827)

6.481 (2.34 to 17.952)

0.0003

  1. ACTH, adreno corticotropic hormone; AUC, area under the receiver operating characteristic curve; CI, confidence interval; OR: odds ratio; PCT, procalcitonin.