On ICU-admission blood concentrations of SDF-1α(CXCL-12) and expression of its receptor (CXCR4) in adrenal gland. The three groups were compared in bar charts as described in Figure 1, and represent (a) SDF-1α (pMol/L) in studied groups. The Y axis is in logarithmic scale. P are indicative of significant difference(s) between groups: **: P < 0.01, ***: P < 0.001. (b) low magnification of a human adrenal gland (× 40) stained with H&E; and after CP450-21-hydroxylase label (red), showing dominant specific expression in the zona fasciculata, (c) sparse expression of the SDF-1α receptor CXCR4 (green labeling, white arrows) by CP450-21-hydroxylase expressing cells of a human adrenal gland cortex (zona fasciculata, red labeling, magnification × 400) (upper panel), and dominant expression of CXCR4 (green labeling) by adrenal vascular wall cells, surrounded by CP450-21-hydroxylase expressing clusters in zona fasciculata (red labeling, magnification × 400) (lower panel).