Skip to main content

Table 3 Influence of positive end-expiratory pressure on respiratory and haemodynamic data at 26 mmHg intra-abdominal pressure

From: Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model

PEEP, cmH2O 5 8 5 vs 8 12 5 vs 12 15 5 vs 15
FRC, L 1.0 (0.2) * 1.0 (0.3) * NS 1.0 (0.3) * NS 1.0 (0.2) * NS
PaO2, mmHg 213 (24) 215 (21) * NS 212 (21) * NS 212 (23) NS
pPaw, cmH2O 33 (4) * 36 (4) * < 0.001 38 (5) * < 0.001 42 (4) * < 0.001
mPaw, cmH2O 13 (4) * 16 (4) * < 0.001 19 (4) * < 0.001 22 (4) * < 0.001
C dyn, ml/cmH2O 13 (3) * 13 (3) * NS 13 (4) * NS 12 (3) * NS
CO, L/min 3.2 (1.0) 2.6 (0.6) * < 0.001 2.7 (0.9) < 0.001 2.5 (0.8) < 0.001
DO2, ml/min 449 (161) 367 (93) * 0.035 377 (140) 0.029 349 (124) 0.005
SvO2, % 58 (9) 54 (14) 0.007 53 (15) * 0.02 52 (13) 0.045
VO2, ml/min 188 (38) 179 (42) NS 183 (54) NS 165 (32) NS
MAP, mmHg 78 (13) 74 (18) NS 74 (15) * NS 76 (17) * NS
APP, mmHg 52 (14) * 48 (15) * NS 48 (15) NS 49 (17) NS
CVP, mmHg 11 (3) * 12 (2) * NS 13 (2) * 0.012 17 (3) * < 0.001
PAOP, mmHg 9 (2) 11 (4) * 0.024 12 (2) * 0.007 14 (3) * < 0.001
HR, beats/min 72 (10) 78 (14) NS 76 (13) NS 80 (16) NS
SVR, dyn * s/cm5 1,771 (446) 1813 (404) * NS 1,861 (490) * NS 1,891 (419) * NS
SV, ml 44 (12) 37 (14) * 0.024 39 (18) 0.037 33 (12) 0.002
  1. APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. *, significant (P < 0.05) difference compared with baseline IAP. NS, not significant.