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Table 3 Influence of positive end-expiratory pressure on respiratory and haemodynamic data at 26 mmHg intra-abdominal pressure

From: Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model

PEEP, cmH2O

5

8

5 vs 8

12

5 vs 12

15

5 vs 15

FRC, L

1.0 (0.2) *

1.0 (0.3) *

NS

1.0 (0.3) *

NS

1.0 (0.2) *

NS

PaO2, mmHg

213 (24)

215 (21) *

NS

212 (21) *

NS

212 (23)

NS

pPaw, cmH2O

33 (4) *

36 (4) *

< 0.001

38 (5) *

< 0.001

42 (4) *

< 0.001

mPaw, cmH2O

13 (4) *

16 (4) *

< 0.001

19 (4) *

< 0.001

22 (4) *

< 0.001

C dyn, ml/cmH2O

13 (3) *

13 (3) *

NS

13 (4) *

NS

12 (3) *

NS

CO, L/min

3.2 (1.0)

2.6 (0.6) *

< 0.001

2.7 (0.9)

< 0.001

2.5 (0.8)

< 0.001

DO2, ml/min

449 (161)

367 (93) *

0.035

377 (140)

0.029

349 (124)

0.005

SvO2, %

58 (9)

54 (14)

0.007

53 (15) *

0.02

52 (13)

0.045

VO2, ml/min

188 (38)

179 (42)

NS

183 (54)

NS

165 (32)

NS

MAP, mmHg

78 (13)

74 (18)

NS

74 (15) *

NS

76 (17) *

NS

APP, mmHg

52 (14) *

48 (15) *

NS

48 (15)

NS

49 (17)

NS

CVP, mmHg

11 (3) *

12 (2) *

NS

13 (2) *

0.012

17 (3) *

< 0.001

PAOP, mmHg

9 (2)

11 (4) *

0.024

12 (2) *

0.007

14 (3) *

< 0.001

HR, beats/min

72 (10)

78 (14)

NS

76 (13)

NS

80 (16)

NS

SVR, dyn * s/cm5

1,771 (446)

1813 (404) *

NS

1,861 (490) *

NS

1,891 (419) *

NS

SV, ml

44 (12)

37 (14) *

0.024

39 (18)

0.037

33 (12)

0.002

  1. APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. *, significant (P < 0.05) difference compared with baseline IAP. NS, not significant.
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