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Table 2 Influence of positive end-expiratory pressure on respiratory and haemodynamic data at 18 mmHg intra-abdominal pressure

From: Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model

PEEP, cmH2O 5 8 5 vs 8 12 5 vs 12 15 5 vs 15
FRC, L 0.9 (0.3) * 1.0 (0.3) * 0.034 1.0 (0.3) * 0.049 1.1 (0.3) * < 0.001
PaO2, mmHg 215 (32) 218 (20) * NS 222 (23) * NS 216 (26) NS
pPaw, cmH2O 29 (5) * 31 (5) * < 0.001 34 (5) * < 0.001 37 (5) * < 0.001
mPaw, cmH2O 12 (3) * 15 (3) * < 0.001 18 (3) * < 0.001 21 (4) * < 0.001
C dyn, ml/cmH2O 15 (4) * 15 (3) * NS 16 (4) * NS 16 (4) * NS
CO, L/min 3.5 (0.9) 3.4 (0.7) NS 3.4 (0.9) NS 3.1 (0.8) * NS
DO2, ml/min 490 (130) 472 (91) NS 472 (124) * NS 428 (116) * NS
SvO2, % 61 (9) 61 (10) NS 58 (11) * NS 56 (14) * NS
VO2, ml/min 195 (64) 192 (50) NS 202 (55) NS 186 (47) NS
MAP, mmHg 83 (12) 79 (11) * NS 81 (16) * NS 72 (13) * < 0.001
APP, mmHg 65 (13) 62 (12) NS 63 (18) NS 56 (12) 0.013
CVP, mmHg 10 (3) * 11 (2) * NS 13 (4) * < 0.001 15 (1) * < 0.001
PAOP, mmHg 7 (2) 9 (1) * < 0.001 11 (2) * < 0.001 12 (1) * < 0.001
HR, beats/min 73 (16) 72 (14) NS 74 (14) NS 76 (14) NS
SVR, dyn * s/cm5 1,643 (364) 1,600 (217) * NS 1,580 (248) NS 1,491 (275) NS
SV, ml 52 (23) 49 (10) * NS 47 (14) * NS 42 (12) * NS
  1. APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. *, significant (P < 0.05) difference compared with baseline IAP. NS, not significant.