|
PEEP, cmH2O
|
5
|
8
|
5 vs 8
|
12
|
5 vs 12
|
15
|
5 vs 15
|
|---|
|
FRC, L
|
0.9 (0.3) *
|
1.0 (0.3) *
|
0.034
|
1.0 (0.3) *
|
0.049
|
1.1 (0.3) *
|
< 0.001
|
|
PaO2, mmHg
|
215 (32)
|
218 (20) *
|
NS
|
222 (23) *
|
NS
|
216 (26)
|
NS
|
|
pPaw, cmH2O
|
29 (5) *
|
31 (5) *
|
< 0.001
|
34 (5) *
|
< 0.001
|
37 (5) *
|
< 0.001
|
|
mPaw, cmH2O
|
12 (3) *
|
15 (3) *
|
< 0.001
|
18 (3) *
|
< 0.001
|
21 (4) *
|
< 0.001
|
|
C dyn, ml/cmH2O
|
15 (4) *
|
15 (3) *
|
NS
|
16 (4) *
|
NS
|
16 (4) *
|
NS
|
|
CO, L/min
|
3.5 (0.9)
|
3.4 (0.7)
|
NS
|
3.4 (0.9)
|
NS
|
3.1 (0.8) *
|
NS
|
|
DO2, ml/min
|
490 (130)
|
472 (91)
|
NS
|
472 (124) *
|
NS
|
428 (116) *
|
NS
|
|
SvO2, %
|
61 (9)
|
61 (10)
|
NS
|
58 (11) *
|
NS
|
56 (14) *
|
NS
|
|
VO2, ml/min
|
195 (64)
|
192 (50)
|
NS
|
202 (55)
|
NS
|
186 (47)
|
NS
|
|
MAP, mmHg
|
83 (12)
|
79 (11) *
|
NS
|
81 (16) *
|
NS
|
72 (13) *
|
< 0.001
|
|
APP, mmHg
|
65 (13)
|
62 (12)
|
NS
|
63 (18)
|
NS
|
56 (12)
|
0.013
|
|
CVP, mmHg
|
10 (3) *
|
11 (2) *
|
NS
|
13 (4) *
|
< 0.001
|
15 (1) *
|
< 0.001
|
|
PAOP, mmHg
|
7 (2)
|
9 (1) *
|
< 0.001
|
11 (2) *
|
< 0.001
|
12 (1) *
|
< 0.001
|
|
HR, beats/min
|
73 (16)
|
72 (14)
|
NS
|
74 (14)
|
NS
|
76 (14)
|
NS
|
|
SVR, dyn * s/cm5
|
1,643 (364)
|
1,600 (217) *
|
NS
|
1,580 (248)
|
NS
|
1,491 (275)
|
NS
|
|
SV, ml
|
52 (23)
|
49 (10) *
|
NS
|
47 (14) *
|
NS
|
42 (12) *
|
NS
|
- APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. *, significant (P < 0.05) difference compared with baseline IAP. NS, not significant.
