|
PEEP, cmH2O
|
5
|
8
|
5 vs 8
|
12
|
5 vs 12
|
15
|
5 vs 15
|
|---|
|
FRC, L
|
1.4 (0.4)
|
1.5 (0.5)
|
NS
|
1.7 (0.5)
|
0.002
|
1.7 (0.6)
|
< 0.001
|
|
PaO2, mmHg
|
237 (14)
|
240 (19)
|
NS
|
236 (16)
|
NS
|
227 (25)
|
< 0.05
|
|
pPaw, cmH2O
|
21 (6)
|
24 (5)
|
< 0.001
|
27 (5)
|
< 0.001
|
32 (5)
|
< 0.001
|
|
mPaw, cmH2O
|
10 (1)
|
13 (2)
|
< 0.001
|
16 (2)
|
< 0.001
|
19 (1)
|
< 0.001
|
|
C dyn, ml/cmH2O
|
25 (8)
|
25 (9)
|
NS
|
24 (9)
|
NS
|
21 (6)
|
< 0.001
|
|
CO, L/min
|
3.5 (1.0)
|
3.2 (1.0)
|
NS
|
2.7 (0.7)
|
0.009
|
2.5 (0.7)
|
0.002
|
|
DO2, ml/min
|
498 (156)
|
459 (156)
|
NS
|
381 (112)
|
0.006
|
349 (100)
|
< 0.001
|
|
SvO2, %
|
62 (7)
|
55 (11)
|
< 0.05
|
47 (13)
|
< 0.05
|
44 (17)
|
< 0.05
|
|
VO2, ml/min
|
191 (47)
|
209 (70)
|
NS
|
205 (81)
|
NS
|
196 (53)
|
NS
|
|
MAP, mmHg
|
71 (19)
|
67 (15)
|
NS
|
60 (13)
|
0.025
|
56 (21)
|
0.004
|
|
APP, mmHg
|
69 (19)
|
64 (15)
|
NS
|
56 (13)
|
0.01
|
53 (21)
|
0.002
|
|
CVP, mmHg
|
8 (4)
|
8 (3)
|
NS
|
9 (2)
|
NS
|
10 (3)
|
NS
|
|
PAOP, mmHg
|
6 (2)
|
6 (2)
|
NS
|
8 (2)
|
0.004
|
9 (1)
|
< 0.001
|
|
HR, beats/min
|
79 (13)
|
81 (18)
|
NS
|
85 (20)
|
NS
|
89 (24)
|
0.026
|
|
SVR, dyn * s/cm5
|
1,389 (408)
|
1,404 (352)
|
NS
|
1,445 (373)
|
NS
|
1,337 (321)
|
NS
|
|
SV, ml
|
50 (21)
|
44 (13)
|
NS
|
37 (12)
|
0.002
|
33 (10)
|
< 0.001
|
- APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. NS, not significant (P > 0.05).
