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Table 1 Influence of positive end-expiratory pressure on respiratory and haemodynamic data at baseline intra-abdominal pressure

From: Commonly applied positive end-expiratory pressures do not prevent functional residual capacity decline in the setting of intra-abdominal hypertension: a pig model

PEEP, cmH2O 5 8 5 vs 8 12 5 vs 12 15 5 vs 15
FRC, L 1.4 (0.4) 1.5 (0.5) NS 1.7 (0.5) 0.002 1.7 (0.6) < 0.001
PaO2, mmHg 237 (14) 240 (19) NS 236 (16) NS 227 (25) < 0.05
pPaw, cmH2O 21 (6) 24 (5) < 0.001 27 (5) < 0.001 32 (5) < 0.001
mPaw, cmH2O 10 (1) 13 (2) < 0.001 16 (2) < 0.001 19 (1) < 0.001
C dyn, ml/cmH2O 25 (8) 25 (9) NS 24 (9) NS 21 (6) < 0.001
CO, L/min 3.5 (1.0) 3.2 (1.0) NS 2.7 (0.7) 0.009 2.5 (0.7) 0.002
DO2, ml/min 498 (156) 459 (156) NS 381 (112) 0.006 349 (100) < 0.001
SvO2, % 62 (7) 55 (11) < 0.05 47 (13) < 0.05 44 (17) < 0.05
VO2, ml/min 191 (47) 209 (70) NS 205 (81) NS 196 (53) NS
MAP, mmHg 71 (19) 67 (15) NS 60 (13) 0.025 56 (21) 0.004
APP, mmHg 69 (19) 64 (15) NS 56 (13) 0.01 53 (21) 0.002
CVP, mmHg 8 (4) 8 (3) NS 9 (2) NS 10 (3) NS
PAOP, mmHg 6 (2) 6 (2) NS 8 (2) 0.004 9 (1) < 0.001
HR, beats/min 79 (13) 81 (18) NS 85 (20) NS 89 (24) 0.026
SVR, dyn * s/cm5 1,389 (408) 1,404 (352) NS 1,445 (373) NS 1,337 (321) NS
SV, ml 50 (21) 44 (13) NS 37 (12) 0.002 33 (10) < 0.001
  1. APP, abdominal perfusion pressure; Cdyn, dynamic compliance; CO, cardiac output; CVP, central venous pressure; DO2, oxygen delivery; FRC, functional residual capacity; HR, heart rate; MAP, mean arterial pressure; mPaw, mean airway pressure; PaO2, arterial oxygen tension; PAOP, pulmonary artery occlusion pressure; PEEP, positive end-expiratory pressure; pPaw, peak airway pressure; SV, stroke volume; SvO2, mixed venous oxygen saturation; SVR, systemic vascular resistance; VO2, oxygen consumption. Mean (SD) are given. ANOVA and post hoc Student-Newman-Keuls were used for statistical testing. NS, not significant (P > 0.05).