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Table 4 Probability of target T >4 × MIC attainment for various MICs

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

   Adequate PK N (%)
MIC (μg/mL) Target concentration (μg/mL) meropenem (n = 16) ceftazidime (n = 18) cefepime (n = 19) piperacillin-tazobactam (n = 27)
32 128 0 0 0 1 (4)
16 64 0 0 1 (5) 12 (44)
8 32 0 5 (28) 3 (16) 15 (56)
4 16 3 (18) 14 (78) 7 (36) 21 (78)
2 8 12 (75) 18 (100) 15 (79) 25 (93)
1 4 15 (94) 18 (100) 17 (90) 27 (100)
0.5 2 16 (100) 18 (100) 19 (100) 27 (100)
  1. Data are expressed as counts (percentage). In bold: MIC corresponding to European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints for Pseudomonas aeruginosa.
  2. MIC, minimal inhibitory concentration; PK, pharmacok inetics.