Table 4 Probability of target T >4 × MIC attainment for various MICs
From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock
Adequate PK N (%) | |||||
|---|---|---|---|---|---|
MIC (μg/mL) | Target concentration (μg/mL) | meropenem (n = 16) | ceftazidime (n = 18) | cefepime (n = 19) | piperacillin-tazobactam (n = 27) |
32 | 128 | 0 | 0 | 0 | 1 (4) |
16 | 64 | 0 | 0 | 1 (5) | 12 (44) |
8 | 32 | 0 | 5 (28) | 3 (16) | 15 (56) |
4 | 16 | 3 (18) | 14 (78) | 7 (36) | 21 (78) |
2 | 8 | 12 (75) | 18 (100) | 15 (79) | 25 (93) |
1 | 4 | 15 (94) | 18 (100) | 17 (90) | 27 (100) |
0.5 | 2 | 16 (100) | 18 (100) | 19 (100) | 27 (100) |