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Table 2 Pharmacokinetic parameters of the β-lactams

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

  Vd (L/kg) Cmax (μg/mL) AUC (mg.h/mL) CL (mL/min.kg) t1/2 (hours)
Piperacillin-tazobactam (n = 27) 0.38 (0.29-0.43) 123 (72-179) 469 (196-896) 2.02 (1.33-4.26) 2.58 (1.51-3.84)
Meropenem (n = 16) 0.43 (0.31-0.77) 35 (29-46) 132 (91-179) 1.87 (1.23-2.63) 2.05 (1.66-3.36)
Ceftazidime (n = 18) 0.48 (0.36-0.71) 63 (48-78) 522 (392-634) 0.89 (0.63-1.34) 5.84 (4.13-7.39)
Cefepime (n = 19) 0.36 (0.33-0.44) 68 (51-86) 310 (234-422) 1.26 (1.07-1.95) 3.37 (2.26-5.34)
  1. Data are expressed as median [range].
  2. AUC, area under the curve; CL, total clearance; Cmax, peak concentration; t1/2, elimination half-time; Vd, volume of distribution.