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Table 1 Characteristics, hemodynamic and biological data on admission and fluid balance during the first 24 hours (n = 80)

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

Age (years) 63 ± 13
Male/female 51/29
Body mass index 24.8 ± 4.8
APACHE II on admission 22 (18-28)
SOFA on admission 8 (5-10)
Medical/surgical 55/25
COPD 15 (19%)
Diabetes 21 (26%)
Heart disease 30 (38%)
Chronic renal insufficiency 7 (9%)
Liver cirrhosis 12 (15%)
Immunosuppressive drugs 26 (33%)
Malignancy 26 (33%)
Community/hospital infections 25/55
Severe sepsis/septic shock 22/58
Mechanical ventilation 57 (71%)
Acute renal failure 22 (27%)
ICU stay (days) 12 (5-25)
Overall ICU mortality 30 (38%)
Fluid balance (mL/24 h) 2559 ± 2010
   Mean IN (mL/24 h) 4449 ± 1877
   Mean OUT (mL/24 h) 1890 ± 1538
  1. Data are expressed as counts (percentage), median (interquartile range) or mean ± standard deviation.
  2. APACHE, Acute Physiology and Chronic Health Evaluation; COPD, Chronic obstructive pulmonary disease; SOFA, Sequential Organ Failure Assessment.