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Table 1 Characteristics, hemodynamic and biological data on admission and fluid balance during the first 24 hours (n = 80)

From: Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock

Age (years)

63 ± 13

Male/female

51/29

Body mass index

24.8 ± 4.8

APACHE II on admission

22 (18-28)

SOFA on admission

8 (5-10)

Medical/surgical

55/25

COPD

15 (19%)

Diabetes

21 (26%)

Heart disease

30 (38%)

Chronic renal insufficiency

7 (9%)

Liver cirrhosis

12 (15%)

Immunosuppressive drugs

26 (33%)

Malignancy

26 (33%)

Community/hospital infections

25/55

Severe sepsis/septic shock

22/58

Mechanical ventilation

57 (71%)

Acute renal failure

22 (27%)

ICU stay (days)

12 (5-25)

Overall ICU mortality

30 (38%)

Fluid balance (mL/24 h)

2559 ± 2010

   Mean IN (mL/24 h)

4449 ± 1877

   Mean OUT (mL/24 h)

1890 ± 1538

  1. Data are expressed as counts (percentage), median (interquartile range) or mean ± standard deviation.
  2. APACHE, Acute Physiology and Chronic Health Evaluation; COPD, Chronic obstructive pulmonary disease; SOFA, Sequential Organ Failure Assessment.