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Table 6 Hemoglobin values over time with actual and percent change from baseline by treatment

From: A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults

Hgb (g/dL) Lab values over time Change from baseline (actual and percent)
  Baseline Hour 24 Hour 72 Hour 120 to Hour 24 to Hour 72 to Hour 120
100 mg IV Ibuprofen Average 12.3 11.2 11.2 11.0 -1.1 -8.8% -1.3 -8.2% -1.3 -8.8%
  SD 2.5 2.1 1.6 1.8 1.0 7.3 2.0 15.3 2.0 15.9
  N 31 30 28 27 30 30 28 28 27 27
  Min 8.2 6.4 8.2 7.2 -4.0 -23.1% -6.4 -37.0% -7.1 -47.0%
  Max 17.3 15.1 15.3 14.9 0.6 4.6% 3.4 35.1% 3.1 37.8%
200 mg IV Ibuprofen Average 11.4 10.4 10.4 10.5 -1.0 -8.5% -1.0 -7.9% -0.8 -5.5%
  SD 2.2 2.0 1.8 2.0 1.0 8.1 1.3 10.4 1.4 13.2
  N 30 30 26 24 30 30 26 26 24 24
  Min 7.2 6.0 6.5 6.3 -3.3 -22.7% -4.3 -28.9% -3.4 -24.1%
  Max 15.2 14.0 14.6 14.4 0.6 6.2% 1.1 12.7% 2.3 25.3%
400 mg IV Ibuprofen Average 11.4 10.3 10.2 10.4 -1.1 -8.9% -1.2 -9.6% -0.8 -5.3%
  SD 2.1 1.7 1.8 1.2 1.0 8.5 1.5 12.9 1.7 14.4
  N 31 30 31 27 30 30 31 31 27 27
  Min 7.9 7.2 5.6 8.2 -2.8 -22.6% -4.1 -39.8% -4.2 -28.0%
  Max 16.2 14.7 13.2 13.0 1.3 15.3% 2.0 25.0% 2.5 31.3%
Placebo Average 11.6 10.7 10.4 10.4 -0.9 -6.9% -1.3 -9.6% -1.3 -9.1%
  SD 2.3 1.9 1.7 1.7 1.2 12.4 1.5 13.8 1.7 17.8
  N 28 28 27 24 28 28 27 27 24 24
  Min 6.0 7.6 7.6 8.1 -3.0 -26.9% -3.7 -27.8% -4.4 -33.1%
  Max 16.2 14.6 13.3 13.8 2.5 41.7% 1.7 28.3% 3.1 51.7%