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Table 1 Baseline Parameters

From: A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults

 

100 mg IVIb (n = 31)

200 mg IVIb (n = 30)

400 mg IVIb (n = 31)

Placebo

(n = 28)

Total

(n = 120)

N: Critically Ill

14 (45%)

12 (40%)

14 (45%)

13 (46%)

53 (44%)

N: Non-Critically Ill

17 (55%)

18 (60%)

17 (55%)

15 (54%)

67 (56%)

In ICU at BL

17 (55%)

15 (50%)

17 (55%)

16 (57%)

65 (54%)

On Mechanical Ventilation at BL

14 (45%)

12 (40%)

14 (45%)

13 (46%)

53 (44%)

On Presssor Support at BL

2 (7%)

2 (7%)

0 (0%)

0 (0%)

4 (3%)

Age (yrs)

40.1

(± 19.0 SD)

34.5

(± 15.0 SD)

39.2

(± 17.2 SD)

37.0

(± 19.1 SD)

37.8

(± 17.5 SD)

Gender

23 M, 8 F

22 M, 8 F

22 M, 9 F

21 M, 7 F

88 M, 32 F

Race

Asian 10;

Black 5;

Caucasian 13;

Hispanic: 2;

Haitian 1.

Asian 10;

Black 4;

Caucasian 15;

Hispanic 1;

Haitian 0.

Asian 10;

Black 1;

Caucasian 16;

Hispanic 4;

Haitian 0.

Asian 10;

Black 3;

Caucasian 14;

Hispanic: 1;

Haitian 0.

Asian 40;

Black 13;

Caucasian 58;

Hispanic 8;

Haitian 1.

Temperature (/°C)

39.07 ± 0.61

39.07 ± 0.71

39.16 ± 0.72

38.89 ± 0.48

N/A

Highest Temp Prior to BL (°C)

39.4 ± 0.7 SD

39.4 ± 0.6

39.4 ± 0.7

39.2 ± 0.8

39.4 ± 0.7

Heart Rate (bpm)

106.0 ± 20.4

105.4 ± 18.4

102.7 ± 18.4

102.9 ± 15.4

104.3 ± 18.1

Mean Arterial Pressure

81.7 ± 12.9

83.3 ± 11.7

87.8 ± 12.7

88.1 ± 15.6

85.2 ± 13.4

Height

(cm)

170.3 ± 10.3

170.1 ± 10.5

168.2 ± 10.1

168.8 ± 11.8

169.4 (±10.6 SD)

Weight

(kg)

77.9 ± 32.6

80.3 ± 29.2

72.5 ± 23.4

78.4 ± 26.6

77.2 (± 28.0)

Positive Blood Culture

13 (42%)

(8 ± Malaria)

13 (43%)

(10 ± Malaria)

12 (39%)

9 ± Malaria

13 (46%)

10 ± Malaria

51 (43%)

37 ± Malaria

Modified APACHE II

11.4

(± 7.6 SD)

12.0

(± 7.7 SD)

13.4

(± 7.8 SD)

12.5

(± 9.7 SD)

12.3

(± 8.1 SD)

Glasgow Coma Score

3 to 8: 4 (13%)

9 to 12: 3 (10%)

>13:24 (77%)

3 to 8: 6 (20%)

9 to 12: 3 (10%)

>13:21 (70%)

3 to 8: 7 (23%)

9 to 12: 4 (13%)

>13:20 (65%)

3 to 8: 5 (18%)

9 to 12: 3 (11%)

>13:20 (71%)

3 to 8: 22 (18%)

9 to 12: 13 (11%)

>13:85 (71%)

Emerg. PostOp

Elect Post Op

Non Operative

2 (6%)

0 (0%)

29 (94%)

4 (13%)

0 (%)

26 (87%)

2 (6%)

3 (10%)

26 (84%)

1 (4%)

0 (0%)

27 (96%)

9 (%)

3 (%)

108 (%)

Chronic Conditions

(from Modified APACHE II)

Liver 0(0%)

CV 0 (0%)

Resp 1(3%)

Renal 0(0%)

Immun 2(6%)

None 28(90%)

Liver 0(0%)

CV 0 (0%)

Resp 1(3%)

Renal 0 (0%)

Immun 2(7%)

None 27(90%)

Liver 0 (0%)

CV 0 (0%)

Resp 1(3%)

Renal 0 (0%)

Immun1(3%)

None 29 (94%)

Liver 0 (0%)

CV 0 (0%)

Resp 1 (4%)

Renal 0 (0%)

Immun (7%)

None 25 (9%)

Liver 0 0%)

CV 0 (0%)

Resp 4(3%)

Renal 0 (0%)

Immun 7(6%)

None109 (91%)

WBC

11.6 ± 7.2

10.9 ± 6.6

9.6 ± 5.0

11.6 ± 6.4

10.9 ± 6.3

Creatinine (mg/dL)

0.95 ± 0.26

.97 ± 0.25

0.97 ± 0.35

1.0 ± 0.44

0.97 (±0.33)

Hematocrit

(%)

36.8 ± 7.7

34.1 ± 6.5

33.7 ± 6.0

34.5 ± 6.9

34.8 ± 6.8

Hemoglobin (g/dL)

12.3 ± 2.5

11.4 ± 2.2

11.4 ± 2.1

11.6 ± 2.3

11.7 ± 2.3

Platelet Count

221.6

(± 158.7)

189.7

(± 111.3)

173.6

(±116.3)

220.0

(±123.61)

200.9

(± 129.1)

Probable Site Infection

None 1(3%);

Blood 9 (29%);

Lung 9 (29%);

Abdom 2 (6%)

Other 3 (10%)

CNS 2 (6%)

Urine Tr 0 (0%)

Skin/Tis 2 (6%)

Up Resp 2(6%)

GYN 0 (0%)

IV 1(3%)

Unk 2(6%)

None (3%)

Blood 10 (33%)

Lung 7 (23%)

Abdom 4 (13%)

Other 3 (10%)

CNS 3 (10%)

Urine Tr 0(0%)

Skin/Tis1 (3%)

Up Resp 0(0%)

GYN 0 (0%)

IV 0 (0%)

Unk 1 (3%)

None 2 (6%)

Blood 10 (32%)

Lung 9 (29%)

Abdom 1 (3%)

Other 4 (13%)

CNS 1 (3%)

Urine Tr 3 (10%)

Skin/Tis 0 (0%)

Up Resp1 (3%)

GYN 0(0%)

IV 0(0%)

Unk 0(0%)

None 2 (7%)

Blood 11 (39%)

Lung 5 (18%)

Abdom 4 (14%)

Other 1 (4%)

CNS 0 (0%)

Urine Tr 2 (7%)

Skin/Tis1(4%)

Up Resp 0 (0%)

GYN 1 (4%)

IV 0(0%)

Unk 1(4%)

None 6(5%)

Blood 40 (33%)

Lung 30 (25%)

Abdom 11 (9%)

Other 11 (9%)

CNS 6(5%)

Urine Tr 5 (4%)

Skin/Tis 4 (3%)

Up Resp 3 (3%)

GYN (1%)

IV 1(1%)

Unk 2(2%)

  1. BL, Baseline.