Pulse pressure variation and volume responsiveness during acutely increased pulmonary artery pressure: an experimental study

Table 1 Overview of systemic hemodynamic values and blood pressure variation during the whole study protocol

		Baseline	Endotoxin	Baseline for bleeding (after volume expansion)	Bleeding	Retransfusion (after last volume challenge)
HR (beats/min)	Endotoxin	93 ± 14	111 ± 5*	107 ± 9	133 ± 17	112 ± 12
	Control	124 ± 18			119 ± 18	127 ± 9
BPm (mmHg)	Endotoxin	78 ± 10	69 ± 12	97 ± 17	37 ± 12	111 ± 31^†
	Control	68 ± 10			38 ± 7	111 ± 19^‡
PAOP (mmHg)	Endotoxin	8 ± 1	9 ± 2	16 ± 5	7 ± 1	18 ± 5^†§
	Control	5 ± 1			4 ± 2	14 ± 2^‡
CVP (mmHg)	Endotoxin	6 ± 1	8 ± 2*	17 ± 2	5 ± 2	19 ± 4^†§
	Control	4 ± 1			3 ± 2	12 ± 1^‡
PAPm (mmHg)	Endotoxin	18 ± 1	45 ± 6*	46 ± 4	28 ± 3	47 ± 7^†
	Control	14 ± 3			11 ± 2	28 ± 4
SvO₂ (%)	Endotoxin	63 ± 7	55 ± 10	64 ± 9	33 ± 18	64 ± 9^†
	Control	49 ± 5			31 ± 5	69 ± 3^‡
CO (l/min)	Endotoxin	4.4 ± 0.8	2.6 ± 0.9**	5.7 ± 1.0	2.0 ± 0.5	5.8 ± 0.7^†§
	Control	3.4 ± 0.7			2.1 ± 0.8	9.4 ± 1.9^‡
SV (ml)	Endotoxin	48 ± 11	24 ± 8*	53 ± 9	15 ± 4	51 ± 2^†§
	Control	29 ± 11			18 ± 9	74 ± 16^‡
PPV (%)	Endotoxin	13 ± 4	10 ± 4	8 ± 4	27 ± 9	9 ± 3^†
	Control	11 ± 5			26 ± 7	7 ± 5^‡
SPV, Δup (mmHg)	Endotoxin	4 ± 0	2 ± 1	2 ± 0	2 ± 1	2 ± 0
	Control	2 ± 1			3 ± 2	2 ± 2
SPV, Δdown (mmHg)	Endotoxin	3 ± 1	2 ± 1	1 ± 1	5 ± 3	2 ± 1
	Control	5 ± 3			4 ± 7	6 ± 2

Data represent the mean ± standard deviation at the end of each phase. HR, heart rate; BPm, mean arterial blood pressure; PAOP, pulmonary artery occlusion pressure; CVP, central venous pressure; PAPm, mean pulmonary artery pressure; SvO₂, mixed venous oxygen saturation; CO, cardiac output; SV, stroke volume; PPV, pulse pressure variation; SPV, systolic pressure variation. *P < 0.05, **P = 0.06 compared with baseline. ^†P < 0.05 compared with endotoxin plus bleeding. ^‡P < 0.05 compared with bleeding. ^§P < 0.05 compared with endotoxin (paired t test). ^¶P < 0.05 compared with baseline.

ISSN: 1364-8535