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Table 2 Risk factors leading to impaired muscle membrane excitability

From: Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study

Cox' regression with time dependent covariates Hazard ratio 95% CI P
    LL UL  
Univariate      
  SOFA 1.175 1.042 1.324 0.008
  SAPS-II 1.019 0.998 1.04 0.018
  Norepinephrine 1.006 1.002 1.011 0.004
  Dobutamine 1.000 1.000 1.001 0.004
  Midazolam 1.001 1.000 1.001 0.012
  Fentanyl 1.026 1.003 1.048 0.024
  HC in septic shock 1.001 0.999 1.003 0.310
  NMBA (Cisatracurium) 1.027 0.934 1.128 0.58
  Aminoglycoside (Tobramycin) 0.99 0.99 1.007 0.791
  Osmolarity 1.012 0.992 1.032 0.258
  IGFPB-1 1.012 1.004 1.020 0.003
  C-reactive protein 1.058 0.994 1.125 0.075
  IL-6 1.006 1.003 1.009 < 0.0001
  1. Univariate Cox' proportional hazard regression with time dependent covariates for variables considered risk factors impairing muscle membrane excitability (as dependent variable) are shown. For the particular parameter repeated measures of daily cumulative dosages, daily plasma levels or daily score values until first proof of reduced muscle membrane excitability in compound muscle action potential after direct muscle stimulation (dmCMAP) abnormal patients or until ICU discharge in dmCMAP normal patients were included in the analysis. HC, adjunctive hydrocortisone treatment in septic shock; IGFBP-1, insulin-like growth factor-binding protein-1; IL-6, interleukin-6; NMBA, neuromuscular blocking agent; SOFA, sequential organ failure assessment score; SAPS-II, simplified acute physiology score. Hazard ratios (HR) with LL (lower limit) and UL (upper limit), 95% confidence intervals (95% CI) and P values for each variable.