Cox' regression with time dependent covariates | Hazard ratio | 95% CI | P | ||
---|---|---|---|---|---|
 |  |  | LL | UL |  |
Univariate | Â | Â | Â | Â | Â |
 | SOFA | 1.175 | 1.042 | 1.324 | 0.008 |
 | SAPS-II | 1.019 | 0.998 | 1.04 | 0.018 |
 | Norepinephrine | 1.006 | 1.002 | 1.011 | 0.004 |
 | Dobutamine | 1.000 | 1.000 | 1.001 | 0.004 |
 | Midazolam | 1.001 | 1.000 | 1.001 | 0.012 |
 | Fentanyl | 1.026 | 1.003 | 1.048 | 0.024 |
 | HC in septic shock | 1.001 | 0.999 | 1.003 | 0.310 |
 | NMBA (Cisatracurium) | 1.027 | 0.934 | 1.128 | 0.58 |
 | Aminoglycoside (Tobramycin) | 0.99 | 0.99 | 1.007 | 0.791 |
 | Osmolarity | 1.012 | 0.992 | 1.032 | 0.258 |
 | IGFPB-1 | 1.012 | 1.004 | 1.020 | 0.003 |
 | C-reactive protein | 1.058 | 0.994 | 1.125 | 0.075 |
 | IL-6 | 1.006 | 1.003 | 1.009 | < 0.0001 |