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Table 2 Risk factors leading to impaired muscle membrane excitability

From: Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study

Cox' regression with time dependent covariates

Hazard ratio

95% CI

P

   

LL

UL

 

Univariate

     
 

SOFA

1.175

1.042

1.324

0.008

 

SAPS-II

1.019

0.998

1.04

0.018

 

Norepinephrine

1.006

1.002

1.011

0.004

 

Dobutamine

1.000

1.000

1.001

0.004

 

Midazolam

1.001

1.000

1.001

0.012

 

Fentanyl

1.026

1.003

1.048

0.024

 

HC in septic shock

1.001

0.999

1.003

0.310

 

NMBA (Cisatracurium)

1.027

0.934

1.128

0.58

 

Aminoglycoside (Tobramycin)

0.99

0.99

1.007

0.791

 

Osmolarity

1.012

0.992

1.032

0.258

 

IGFPB-1

1.012

1.004

1.020

0.003

 

C-reactive protein

1.058

0.994

1.125

0.075

 

IL-6

1.006

1.003

1.009

< 0.0001

  1. Univariate Cox' proportional hazard regression with time dependent covariates for variables considered risk factors impairing muscle membrane excitability (as dependent variable) are shown. For the particular parameter repeated measures of daily cumulative dosages, daily plasma levels or daily score values until first proof of reduced muscle membrane excitability in compound muscle action potential after direct muscle stimulation (dmCMAP) abnormal patients or until ICU discharge in dmCMAP normal patients were included in the analysis. HC, adjunctive hydrocortisone treatment in septic shock; IGFBP-1, insulin-like growth factor-binding protein-1; IL-6, interleukin-6; NMBA, neuromuscular blocking agent; SOFA, sequential organ failure assessment score; SAPS-II, simplified acute physiology score. Hazard ratios (HR) with LL (lower limit) and UL (upper limit), 95% confidence intervals (95% CI) and P values for each variable.