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Table 1 Patients' characteristics within the first week after ICU admission in patients without and with critical illness myopathy

From: Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study

dmCMAP   Normal Abnormal P
Number of patients Total 40 18 22  
Age Years 42 (24.3/58.5) 58 (42.5/68.3) 0.06b
Gender male/female 12/6 15/7 1a
Survival survivor/non-survivor 17/1 14/8 0.03a
BMI kg/m2 24.8 (20.5/26.6) 25.4 (23.3/29.7) 0.19b
Reason of ICU admission Multiple trauma. total n (%) 11 (61.1) 10 (45.5) 0.25a
  Pneumonia. total n (%) 3 (16.7) 7 (31.8)  
  Abdominal cancer. total n (%) 2 (11.1) 5 (22.7)  
  Others. total n (%) 2 (11.1) 0  
ICU admission SAPS-II 31.5 (23.8/42) 41.0 (36.3/48.3) 0.02b
  SOFA 8.0 (5.8/10.3) 10.0 (7/12.5) 0.07b
  White blood cell count (1/nl) 9.6 (8.4/12.6) 8.8 (6.5/11.6) 0.26b
  Plasma CRP (mg/dl) 17.1 (11.03/23.9) 17.2 (10.8/26.1) 0.72b
  Plasma urea (mg/dl) 33 (21/53.8) 55.5 (33.8/102.5) 0.001b
  Plasma creatinine (mg/dl) 1.02 (0.73/1.24) 1.5 (0.92/2.6) 0.001b
  PaO2/FiO2 205.5 (183/247.5) 177.4 (91/256) 0.4b
  Plasma lactate (mmol/l) 2.15 (1.5/2.5) 3.35 (2.02/6.02) 0.02b
  Plasma pH 7.36 (7.3/7.47) 7.28 (7.2/7.48) 0.08b
Inflammation day 1-8 (cum. %) SIRS 75.0 (52.2/100) 87.5 (71.9/100) 0.18a
  Severe sepsis 25.0 (0/62.5) 68.8 (9.4/87.5) 0.075a
  Septic shock 12.5 (0/50) 56.2 (0/87.5) 0.022a
Organ dysfunction day 1-8 (cum. %) Coagulation 18.75 (0/77.7) 62.5 (9.4/100) 0.26a
  Lung 33.3 (18.75/75) 68.75 (25/100) 0.15a
  Renal 0 (0/0) 0 (0/56.3) 0.21a
  Liver 0 (0/31.3) 25 (0/50) 0.12a
  Metabolic acidosis 0 (0/18.75) 12.5 (0/50) 0.08a
  GCS < 13 0 (0/7.14) 6.25 (0/75) 0.2a
  Organ dysfunction > 2 0 (0/0) 37.5 (0/62.5) 0.003a
Drugs days 1 to 8 (% pat; cum dosage per pat.) Norepinephrine (mg) 61.1; 8.9 (2.7/35.6) 91; 60.1 (27.5/84.1) 0.05b; 0.003b
  Dobutamine (mg) 27.8; 581 (259/951) 54.5; 1975 (958/4399) 0.12b; 0.019b
  NMBA (mg) 55.6; 10 (9.3/20) 63.6; 27.5 (17.5/45) 0.75b; 0.016b
  Aminoglycosides (mg) 16.7; 1440 (1260/1440) 27.3; 420 (320/620) 0.48b; 0.024b
  Hydrocortisone (mg) 16.7; 719 (501/719) 36.4; 836 (598/963) 0.29b; 1.0b
  Carbohydrates (kcal/kg) 94.4; 64.7 (29.2/103.2) 95.5; 59.7 (50.6/83.4) 1.0b; 0.95b
  Insulin (IU) 100; 237.8 (165/370) 95.5; 331.2 (155/590) 1.0b; 0.2b
  Fentanyl (mg) 94.4; 18.4 (7/26.5) 95.5; 36 (19.8/69.5) 1.0b; 0.006b
  Midazolam (mg) 77.8; 726 (318/1292) 90.9; 1702 (810/3593) 0.38b; 0.05b
  1. Myopathy according to direct muscle stimulated compound muscle action potential (dmCMAP) at onset of critical illness, normal (≥3 mV) and abnormal (< 3 mV); parameters are calculated upon ICU admission or within eight days after ICU admission.
  2. BMI, body mass index; CRP, C-reactive protein; GCS, Glasgow Coma Scale; NMBA, neuromuscular blocking agent; PaO2/FiO2, index of arterial oxygenation efficiency corresponding to ratio of partial pressure of arterial O2 to the fraction of inspired O2; SAPS-II, simplified acute physiology score; SIRS, systemic inflammatory response syndrome; SOFA, sequential organ failure assessment score; (cum. %), cumulative fractions of presented parameters calculated by sum of days fulfilling criteria of a particular parameter divided by total days of ICU presence within the first eight days after ICU admission; (% patients), proportion of patients; (cum. dosage), cumulative drug dose within the first eight days after ICU admission. Qualitative data are given as proportions (%). Continuous data and cumulative fractions are given as median and 25%/75% percentile; aFisher's exact test, bMann-Whitney U rank test.