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Table 1 Patients' characteristics within the first week after ICU admission in patients without and with critical illness myopathy

From: Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study

dmCMAP

 

Normal

Abnormal

P

Number of patients

Total 40

18

22

 

Age

Years

42 (24.3/58.5)

58 (42.5/68.3)

0.06b

Gender

male/female

12/6

15/7

1a

Survival

survivor/non-survivor

17/1

14/8

0.03a

BMI

kg/m2

24.8 (20.5/26.6)

25.4 (23.3/29.7)

0.19b

Reason of ICU admission

Multiple trauma. total n (%)

11 (61.1)

10 (45.5)

0.25a

 

Pneumonia. total n (%)

3 (16.7)

7 (31.8)

 
 

Abdominal cancer. total n (%)

2 (11.1)

5 (22.7)

 
 

Others. total n (%)

2 (11.1)

0

 

ICU admission

SAPS-II

31.5 (23.8/42)

41.0 (36.3/48.3)

0.02b

 

SOFA

8.0 (5.8/10.3)

10.0 (7/12.5)

0.07b

 

White blood cell count (1/nl)

9.6 (8.4/12.6)

8.8 (6.5/11.6)

0.26b

 

Plasma CRP (mg/dl)

17.1 (11.03/23.9)

17.2 (10.8/26.1)

0.72b

 

Plasma urea (mg/dl)

33 (21/53.8)

55.5 (33.8/102.5)

0.001b

 

Plasma creatinine (mg/dl)

1.02 (0.73/1.24)

1.5 (0.92/2.6)

0.001b

 

PaO2/FiO2

205.5 (183/247.5)

177.4 (91/256)

0.4b

 

Plasma lactate (mmol/l)

2.15 (1.5/2.5)

3.35 (2.02/6.02)

0.02b

 

Plasma pH

7.36 (7.3/7.47)

7.28 (7.2/7.48)

0.08b

Inflammation day 1-8

(cum. %)

SIRS

75.0 (52.2/100)

87.5 (71.9/100)

0.18a

 

Severe sepsis

25.0 (0/62.5)

68.8 (9.4/87.5)

0.075a

 

Septic shock

12.5 (0/50)

56.2 (0/87.5)

0.022a

Organ dysfunction day 1-8

(cum. %)

Coagulation

18.75 (0/77.7)

62.5 (9.4/100)

0.26a

 

Lung

33.3 (18.75/75)

68.75 (25/100)

0.15a

 

Renal

0 (0/0)

0 (0/56.3)

0.21a

 

Liver

0 (0/31.3)

25 (0/50)

0.12a

 

Metabolic acidosis

0 (0/18.75)

12.5 (0/50)

0.08a

 

GCS < 13

0 (0/7.14)

6.25 (0/75)

0.2a

 

Organ dysfunction > 2

0 (0/0)

37.5 (0/62.5)

0.003a

Drugs days 1 to 8

(% pat; cum dosage per pat.)

Norepinephrine (mg)

61.1; 8.9 (2.7/35.6)

91; 60.1 (27.5/84.1)

0.05b; 0.003b

 

Dobutamine (mg)

27.8; 581 (259/951)

54.5; 1975 (958/4399)

0.12b; 0.019b

 

NMBA (mg)

55.6; 10 (9.3/20)

63.6; 27.5 (17.5/45)

0.75b; 0.016b

 

Aminoglycosides (mg)

16.7; 1440 (1260/1440)

27.3; 420 (320/620)

0.48b; 0.024b

 

Hydrocortisone (mg)

16.7; 719 (501/719)

36.4; 836 (598/963)

0.29b; 1.0b

 

Carbohydrates (kcal/kg)

94.4; 64.7 (29.2/103.2)

95.5; 59.7 (50.6/83.4)

1.0b; 0.95b

 

Insulin (IU)

100; 237.8 (165/370)

95.5; 331.2 (155/590)

1.0b; 0.2b

 

Fentanyl (mg)

94.4; 18.4 (7/26.5)

95.5; 36 (19.8/69.5)

1.0b; 0.006b

 

Midazolam (mg)

77.8; 726 (318/1292)

90.9; 1702 (810/3593)

0.38b; 0.05b

  1. Myopathy according to direct muscle stimulated compound muscle action potential (dmCMAP) at onset of critical illness, normal (≥3 mV) and abnormal (< 3 mV); parameters are calculated upon ICU admission or within eight days after ICU admission.
  2. BMI, body mass index; CRP, C-reactive protein; GCS, Glasgow Coma Scale; NMBA, neuromuscular blocking agent; PaO2/FiO2, index of arterial oxygenation efficiency corresponding to ratio of partial pressure of arterial O2 to the fraction of inspired O2; SAPS-II, simplified acute physiology score; SIRS, systemic inflammatory response syndrome; SOFA, sequential organ failure assessment score; (cum. %), cumulative fractions of presented parameters calculated by sum of days fulfilling criteria of a particular parameter divided by total days of ICU presence within the first eight days after ICU admission; (% patients), proportion of patients; (cum. dosage), cumulative drug dose within the first eight days after ICU admission. Qualitative data are given as proportions (%). Continuous data and cumulative fractions are given as median and 25%/75% percentile; aFisher's exact test, bMann-Whitney U rank test.