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Table 3 Perioperative period ('per protocol' analysis)

From: Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study

Parameters Vigileo group Control group P value
  n = 51 (85%) n = 54 (90%)  
Baseline measurement    
   MAP (mmHg) 103 ± 13 103 ± 16 0.948
   CVP (mmHg) 8 ± 2 9 ± 4 0.362
   HR (beats/min) 74 ± 13 74 ± 10 0.851
   CI (ml/min/m2) 3 ± 0.64 N/A  
   SVV (%) 13 ± 5 N/A  
End of surgery    
   MAP (mmHg) 92 ± 12* 91 ± 14* 0.702
   CVP (mmHg) 10 ± 3* 10 ± 3 0.439
  *(P = 0.0002 vs. baseline)   
   HR (beats/min) 70 ± 11* 73 ± 15 0.264
  *(P = 0.0108 vs. baseline)   
   CI (ml/min/m2) 3.6 ± 0.7* N/A  
  *(P < 0.0001 vs. baseline)   
   SVV (%) 7 ± 2* N/A  
  *(P < 0.0001 vs. baseline)   
   Number of hypotensive periods intraoperatively 2 (1-2) 3.5 (2-6) 0.0001
   Length of anesthesia (min) 184 ± 46 202 ± 53 0.072
   Length of surgery (min) 163 ± 44 176 ± 55 0.214
   Length of aortic cross-clamping 61.5 ± 35 57 ± 35 0.592
   Crystalloids (ml) 2321 ± 681 2459 ± 930 0.386
   Colloids (ml) 1425 (1000-1500) 1000 (540-1250) 0.0028
   Blood (ml) 0 (0-566) 270 (0-578) 0.633
   Fresh frozen plasma (ml) 0 (0-540) 0 (0-540) 0.793
   Estimated blood loss (ml) 700 (500-1200) 800 (400-1325) 0.511
   Diuresis (ml/kg/h) 1.13 (0.76-1.85) 0.896 (0.56-1.43) 0.068
   Norepinephrine 3 (5.88%) 11 (20.37%) 0.058
   Dobutamine 2 (3.92%) 0 (0%) 0.451
   Vasodilatation therapy 5 (9.8%) 3 (5.56%) 0.652
After eight hours on ICU    
   Crystalloids (ml) 1587 ± 371 1528 ± 475 0.485
   Colloids (ml) 0 (0-500) 0 (0-250) 0.887
   Blood (ml) 0 (0-0) 0 (0-0) 0.746
   Fresh frozen plasma (ml) 0 (0-0) 0 (0-0) 0.744
   Diuresis (ml/kg/h) 1.18 (0.79-1.89) 1.08 (0.83-1.89) 0.886
   Norepinephrine 7 (13.72%) 6 (11.11%) 0.913
   Dobutamine 1 (1.96%) 0 (0%) 0.977
   Vasodilatation therapy 10 (19.61%) 9 (16.67%) 0.891
   Diuretic support 13 (25.49%) 17 (31.48%) 0.643
   SOFA (8 hours) 3 (2-5.25) 3 (1-4) 0.474
   SOFA (24 hours) 2 (2-4) 3 (1.5-4) 0.541
  1. Perioperative period analyzed only for patients whose intraoperative protocol was carried in full extent. Values are presented as absolute (percentage), mean ± standard deviation or median (interquartile range).
  2. CI, cardiac index; CVP, central venous pressure; HR, heart rate; MAP, mean arterial pressure; N/A, not applicable; SOFA, Sequential Organ Failure Assessment; SVV, stroke volume variation.