Table 3 Perioperative period ('per protocol' analysis)

Baseline measurement

   MAP (mmHg)

103 ± 13

103 ± 16

0.948

   CVP (mmHg)

8 ± 2

9 ± 4

0.362

   HR (beats/min)

74 ± 13

74 ± 10

0.851

   CI (ml/min/m²)

3 ± 0.64

N/A

   SVV (%)

13 ± 5

N/A

End of surgery

   MAP (mmHg)

92 ± 12*

91 ± 14*

0.702

   CVP (mmHg)

10 ± 3*

10 ± 3

0.439

*(P = 0.0002 vs. baseline)

   HR (beats/min)

70 ± 11*

73 ± 15

0.264

*(P = 0.0108 vs. baseline)

   CI (ml/min/m²)

3.6 ± 0.7*

N/A

*(P < 0.0001 vs. baseline)

   SVV (%)

7 ± 2*

N/A

*(P < 0.0001 vs. baseline)

   Number of hypotensive periods intraoperatively

2 (1-2)

3.5 (2-6)

0.0001

   Length of anesthesia (min)

184 ± 46

202 ± 53

0.072

   Length of surgery (min)

163 ± 44

176 ± 55

0.214

   Length of aortic cross-clamping

61.5 ± 35

57 ± 35

0.592

   Crystalloids (ml)

2321 ± 681

2459 ± 930

0.386

   Colloids (ml)

1425 (1000-1500)

1000 (540-1250)

0.0028

   Blood (ml)

0 (0-566)

270 (0-578)

0.633

   Fresh frozen plasma (ml)

0 (0-540)

0 (0-540)

0.793

   Estimated blood loss (ml)

700 (500-1200)

800 (400-1325)

0.511

   Diuresis (ml/kg/h)

1.13 (0.76-1.85)

0.896 (0.56-1.43)

0.068

   Norepinephrine

3 (5.88%)

11 (20.37%)

0.058

   Dobutamine

2 (3.92%)

0 (0%)

0.451

   Vasodilatation therapy

5 (9.8%)

3 (5.56%)

0.652

After eight hours on ICU

   Crystalloids (ml)

1587 ± 371

1528 ± 475

0.485

   Colloids (ml)

0 (0-500)

0 (0-250)

0.887

   Blood (ml)

0 (0-0)

0 (0-0)

0.746

   Fresh frozen plasma (ml)

0 (0-0)

0 (0-0)

0.744

   Diuresis (ml/kg/h)

1.18 (0.79-1.89)

1.08 (0.83-1.89)

0.886

   Norepinephrine

7 (13.72%)

6 (11.11%)

0.913

   Dobutamine

1 (1.96%)

0 (0%)

0.977

   Vasodilatation therapy

10 (19.61%)

9 (16.67%)

0.891

   Diuretic support

13 (25.49%)

17 (31.48%)

0.643

   SOFA (8 hours)

3 (2-5.25)

3 (1-4)

0.474

   SOFA (24 hours)

2 (2-4)

3 (1.5-4)

0.541