Table 1 Inclusion criteria

   Operation duration more than 120 minutes and opened peritoneal cavity

   Presumed blood loss more than 1,000 ml

Patient related (at least one of them)

   Ischemic heart disease or severe heart dysfunction

   Chronic obstructive pulmonary disease (moderate to severe)

   Age above 70 years

   ASA 3 or more for other reasons (chronic kidney disease, diabetes etc.)

Exclusion criteria

   Irregular heart rhythm

   Body weight less than 55 kg or more than 140 kg

   Age under 18 years