| HYPO | NORMO | HYPER |
---|
 | NR | RM-CPAP | NR | RM-CPAP | NR | RM-CPAP |
---|
Lung | 2 (2-3) | 2 (2-2.25) | 2 (1.75-3) | 2 (2-3) | 3 (2-3.25) | 4‡§ (3-4) |
Kidney | 2 (2-3) | 3 (2-3.25) | 3 (1.75-3) | 3 (2-3) | 3 (2.75-3.25) | 4 (3-4) |
Liver | 2 (2-2.25) | 2 (2-3) | 2 (2-3) | 2 (2-3) | 2 (2-3) | 3 (2.75-3.25) |
Villi | 3 (2-3) | 3 (2.75-3.25) | 3 (2-3) | 3 (2.75-3) | 3 (3-4) | 4 (2.75-4) |
- Semi-quantitative analysis of apoptotic cells in lung, kidney, liver, and small intestine villi. The apoptotic findings were graded as negative = 0, slight = 1, moderate = 2, high = 3 and severe = 4 in 10 non-coincident microscopic fields (× 400 magnification). A mean score was then calculated (0 = normal lung parenchyma; 1 = 1-25%; 2 = 26 to 50%; 3 = 51 to 75%; 4 = 76 to 100% of structures altered). Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR). Values are the median (25th percentile to 75th percentile) of five animals per group. ‡Significantly different from HYPO-RM-CPAP (P < 0.05). §Significantly different from NORMO-RM-CPAP (P < 0.05).