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Table 5 Cell apoptosis

From: Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury

 

HYPO

NORMO

HYPER

 

NR

RM-CPAP

NR

RM-CPAP

NR

RM-CPAP

Lung

2

(2-3)

2

(2-2.25)

2

(1.75-3)

2

(2-3)

3

(2-3.25)

4‡§

(3-4)

Kidney

2

(2-3)

3

(2-3.25)

3

(1.75-3)

3

(2-3)

3

(2.75-3.25)

4

(3-4)

Liver

2

(2-2.25)

2

(2-3)

2

(2-3)

2

(2-3)

2

(2-3)

3

(2.75-3.25)

Villi

3

(2-3)

3

(2.75-3.25)

3

(2-3)

3

(2.75-3)

3

(3-4)

4

(2.75-4)

  1. Semi-quantitative analysis of apoptotic cells in lung, kidney, liver, and small intestine villi. The apoptotic findings were graded as negative = 0, slight = 1, moderate = 2, high = 3 and severe = 4 in 10 non-coincident microscopic fields (× 400 magnification). A mean score was then calculated (0 = normal lung parenchyma; 1 = 1-25%; 2 = 26 to 50%; 3 = 51 to 75%; 4 = 76 to 100% of structures altered). Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR). Values are the median (25th percentile to 75th percentile) of five animals per group. ‡Significantly different from HYPO-RM-CPAP (P < 0.05). §Significantly different from NORMO-RM-CPAP (P < 0.05).