Skip to main content

Table 5 Cell apoptosis

From: Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury

  HYPO NORMO HYPER
  NR RM-CPAP NR RM-CPAP NR RM-CPAP
Lung 2
(2-3)
2
(2-2.25)
2
(1.75-3)
2
(2-3)
3
(2-3.25)
4‡§
(3-4)
Kidney 2
(2-3)
3
(2-3.25)
3
(1.75-3)
3
(2-3)
3
(2.75-3.25)
4
(3-4)
Liver 2
(2-2.25)
2
(2-3)
2
(2-3)
2
(2-3)
2
(2-3)
3
(2.75-3.25)
Villi 3
(2-3)
3
(2.75-3.25)
3
(2-3)
3
(2.75-3)
3
(3-4)
4
(2.75-4)
  1. Semi-quantitative analysis of apoptotic cells in lung, kidney, liver, and small intestine villi. The apoptotic findings were graded as negative = 0, slight = 1, moderate = 2, high = 3 and severe = 4 in 10 non-coincident microscopic fields (× 400 magnification). A mean score was then calculated (0 = normal lung parenchyma; 1 = 1-25%; 2 = 26 to 50%; 3 = 51 to 75%; 4 = 76 to 100% of structures altered). Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR). Values are the median (25th percentile to 75th percentile) of five animals per group. ‡Significantly different from HYPO-RM-CPAP (P < 0.05). §Significantly different from NORMO-RM-CPAP (P < 0.05).