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Table 3 Arterial blood gases and static lung elastance

From: Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury

  

HYPO

NORMO

HYPER

  

NR

RM-CPAP

NR

RM-CPAP

NR

RM-CPAP

PaO2

(mmHg)

BASELINE ZEEP

225 ± 96

190 ± 38

164 ± 40

228 ± 114

147 ± 64

212 ± 88

 

END

466 ± 32*

430 ± 69*

485 ± 45*

537 ± 40*

231 ± 20**#

380 ± 42†§

PaCO2 (mmHg)

BASELINE ZEEP

31 ± 2

30 ± 7

34 ± 4

37 ± 5

35 ± 3

37 ± 7

 

END

34 ± 6

32 ± 5

28 ± 9

37 ± 3

39 ± 12

35 ± 11

pHa

BASELINE ZEEP

7.30 ± 0.10

7.23 ± 0.01

7.27 ± 0.10

7.25 ± 0.10

7.24 ± 0.10

7.22 ± 0.01

 

END

7.11 ± 0.10

7.13 ± 0.01

7.19 ± 0.10

7.21 ± 0.10

7.23 ± 0.10

7.22 ± 0.01

Est,L (cmH2O.ml-1)

BASELINE

3.4 ± 0.3

3.2 ± 0.5

3.0 ± 0.3

3.1 ± 0.3

3.3 ± 0.5

3.3 ± 0.5

 

END

3.1 ± 0.4

1.2 ± 0.1*†

2.6 ± 0.1

2.5 ± 0.4‡

4.1 ± 0.7#‡

2.8 ± 0.6†

  1. Arterial oxygen partial pressure (PaO2, mmHg), arterial carbon dioxide partial pressure (PaCO2), and arterial pH (pHa) measured at BASELINE-ZEEP and after one hour of mechanical ventilation (END). Static lung elastance (Est,L) measured at BASELINE (positive end-expiratory pressure = 5 cmH2O) and at END. Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR). Values are mean ± standard error of the mean of six rats in each group. *Significantly different from BASELINE (P < 0.05). †Significantly different from NR (P < 0.05). **Significantly different from HYPO-NR (P < 0.05). ‡Significantly different from HYPO-RM-CPAP (P < 0.05). #Significantly different from NORMO-NR (P < 0.05). §Significantly different from NORMO-RM-CPAP (P < 0.05).