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Table 3 Arterial blood gases and static lung elastance

From: Hypervolemia induces and potentiates lung damage after recruitment maneuver in a model of sepsis-induced acute lung injury

   HYPO NORMO HYPER
   NR RM-CPAP NR RM-CPAP NR RM-CPAP
PaO2
(mmHg)
BASELINE ZEEP 225 ± 96 190 ± 38 164 ± 40 228 ± 114 147 ± 64 212 ± 88
  END 466 ± 32* 430 ± 69* 485 ± 45* 537 ± 40* 231 ± 20**# 380 ± 42†§
PaCO2 (mmHg) BASELINE ZEEP 31 ± 2 30 ± 7 34 ± 4 37 ± 5 35 ± 3 37 ± 7
  END 34 ± 6 32 ± 5 28 ± 9 37 ± 3 39 ± 12 35 ± 11
pHa BASELINE ZEEP 7.30 ± 0.10 7.23 ± 0.01 7.27 ± 0.10 7.25 ± 0.10 7.24 ± 0.10 7.22 ± 0.01
  END 7.11 ± 0.10 7.13 ± 0.01 7.19 ± 0.10 7.21 ± 0.10 7.23 ± 0.10 7.22 ± 0.01
Est,L (cmH2O.ml-1) BASELINE 3.4 ± 0.3 3.2 ± 0.5 3.0 ± 0.3 3.1 ± 0.3 3.3 ± 0.5 3.3 ± 0.5
  END 3.1 ± 0.4 1.2 ± 0.1*† 2.6 ± 0.1 2.5 ± 0.4‡ 4.1 ± 0.7#‡ 2.8 ± 0.6†
  1. Arterial oxygen partial pressure (PaO2, mmHg), arterial carbon dioxide partial pressure (PaCO2), and arterial pH (pHa) measured at BASELINE-ZEEP and after one hour of mechanical ventilation (END). Static lung elastance (Est,L) measured at BASELINE (positive end-expiratory pressure = 5 cmH2O) and at END. Animals were randomly assigned to hypovolemia (HYPO), normovolemia (NORMO) or hypervolemia (HYPER) with recruitment maneuver (RM-CPAP) or not (NR). Values are mean ± standard error of the mean of six rats in each group. *Significantly different from BASELINE (P < 0.05). †Significantly different from NR (P < 0.05). **Significantly different from HYPO-NR (P < 0.05). ‡Significantly different from HYPO-RM-CPAP (P < 0.05). #Significantly different from NORMO-NR (P < 0.05). §Significantly different from NORMO-RM-CPAP (P < 0.05).