Table 1 Pooled mean antimicrobial resistance of selected pathogens in German intensive care units (number of ICUs), 2001 to 2008
Resistant pathogen (number tested against each antimicrobial) | 2001 (n = 36) | 2002 (n = 35) | 2003 (n = 38) | 2004 (n = 40) | 2005 (n = 44) | 2006 (n = 46) | 2007 (n = 45) | 2008 (n = 45) | P value* |
|---|---|---|---|---|---|---|---|---|---|
Methicillin-resistant Staphylococcus aureus (27,446) | 26.0 | 22.4 | 20.9 | 19.5 | 22.6 | 22.2 | 20.6 | 19.5 | 0.006 (-) |
Vancomycin-resistant Enterococcus faecium (6,331) | 2.3 | 1.2 | 1.2 | 5.4 | 5.4 | 2.2 | 3.6 | 8.2 | 0.008 (+) |
3GC-resistant Escherichia coli (18,425) | 1.2 | 1.8 | 2.9 | 3.8 | 3.7 | 5.1 | 11.1 | 10.5 | < 0.001 (+) |
Ciprofloxacin-resistant Escherichia coli (16,184) | 8.3 | 11.9 | 14.1 | 16.5 | 18.2 | 16.4 | 20.9 | 24.2 | < 0.001 (+) |
3GC-resistant Klebsiella pneumoniae (7,457) | 3.8 | 12.2 | 5.9 | 6.5 | 6.5 | 6.5 | 10.4 | 15.1 | < 0.007 (+) |
Imipenem-resistant Pseudomonas aeruginosa (10,468) | 24.0 | 22.8 | 23.5 | 23.8 | 22.0 | 24.4 | 27.0 | 25.5 | No trend |
Ciprofloxacin-resistant Pseudomonas aeruginosa (11,590) | 19.7 | 18.4 | 15.6 | 19.5 | 17.4 | 19.3 | 17.0 | 16.0 | No trend |
Imipenem-resistant Acinetobacter baumannii (2,014) | 1.1 | 0.7 | 1.0 | 2.5 | 6.3 | 20.3 | 9.7 | 4.5 | 0.002 (+) |
Imipenem-resistant Klebsiella pneumoniae (5,732) | 0.4 | 0.2 | 0.3 | 0.3 | 0.0 | 0.3 | 0.4 | 1.1 | NA |