Figure 2From: Dramatic increase of third-generation cephalosporin-resistant E. coli in German intensive care units: secular trends in antibiotic drug use and bacterial resistance, 2001 to 2008Change in antibiotic consumption in German intensive care units from 2001 to 2008. DDD, defined daily doses; pd, patient-days; 1&2GC, first-generation and second-generation cephalosporins; 3&4GC, third-generation and fourth-generation cephalosporins. P value for the linear regression coefficient and trend (increase, +; decrease, -) in parentheses.Back to article page