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Table 3 Hemodynamic changes in patients with (responders) and without (nonresponders) increase in stroke volume after a volume challenge

From: Pulse-pressure variation and hemodynamic response in patients with elevated pulmonary artery pressure: a clinical study

 

Cardiac surgery

Sepsis

P value

 

Before

After

Before

After

V

V/R

V/R/D

Stroke volume (ml/m2)

    

0.001

 

0.699

   All

30 ± 9

31 ± 7

34 ± 6

36 ± 7

   

   Responders

24 ± 4

29 ± 4

32 ± 5

37 ± 7

   

   Nonresponders

32 ± 9

32 ± 8

35 ± 6

35 ± 7

   

Pulmonary artery occlusion pressure (mm Hg)

    

0.001

0.280

0.701

   All

13 ± 3

14 ± 4

16 ± 4

18 ± 4

   

   Responders

12 ± 1

14 ± 2

13 ± 4

18 ± 3

   

   Nonresponders

13 ± 4

15 ± 4

16 ± 4

18 ± 4

   

Central venous pressure (mm Hg)

    

0.001

0.724

0.593

   All

12 ± 4

13 ± 4

12 ± 5

14 ± 5

   

   Responders

12 ± 3

13 ± 4

10 ± 3

12 ± 3

   

   Nonresponders

12 ± 4

13 ± 4

13 ± 5

15 ± 5

   

Mean pulmonary arterial pressure (mm Hg)

    

0.001

0.158

0.175

   All

26 ± 4

28 ± 5

33 ± 7

35 ± 6

   

   Responders

27 ± 3

29 ± 3

32 ± 6

34 ± 7

   

   Nonresponders

26 ± 5

27 ± 5

34 ± 7

35 ± 6

   

Mean arterial pressure (mm Hg)

    

0.001

0.206

0.255

   All

67 ± 8

70 ± 9

58 ± 7

60 ± 7

   

   Responders

69 ± 7

74 ± 7

61 ± 7

63 ± 9

   

   Nonresponders

66 ± 9

69 ± 10

57 ± 7

59 ± 5

   

Heart rate (beats/min)

    

0.071

0.438

0.343

   All

92 ± 5

92 ± 4

116 ± 22

114 ± 22

   

   Responders

91 ± 4

91 ± 4

120 ± 24

117 ± 24

   

   Nonresponders

92 ± 5

92 ± 5

114 ± 22

113 ± 22

   

Right ventricular end-diastolic volume (ml/m2)

    

0.245

0.385

0.378

   All

103 ± 26

101 ± 25

122 ± 23

122 ± 24

   

   Responders

103 ± 38

101 ± 34

124 ± 20

122 ± 21

   

   Nonresponders

103 ± 21

101 ± 22

121 ± 25

122 ± 26

   

Right ventricular ejection fraction (%)

    

0.108

0.055

0.836

   All

30 ± 10

32 ± 10

30 ± 6

29 ± 6

   

   Responders

26 ± 9

28 ± 9

27 ± 5

28 ± 6

   

   Nonresponders

32 ± 10

33 ± 10

31 ± 6

30 ± 6

   

Pulse-pressure variation (%)

    

0.307

0.573

0.386

   All

22 ± 18

20 ± 17

34 ± 29

33 ± 28

   

   Responders

22 ± 17

15 ± 8

38 ± 32

38 ± 38

   

   Nonresponders

22 ± 19

22 ± 19

32 ± 29

30 ± 24

   
  1. Values are expressed as mean ± SD. Bold indicated significant P values (P < 0.05).
  2. V, Effect of volume; V/R, volume-response interaction; V/R/D, volume-response-diagnosis interaction.