Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections

Table 3 Logistic model for the prediction of serious complications or death using proADM and all CURB covariates

	Serious complications			Death
	OR	95% CI	P	OR	95% CI	P
Intercept	0.08	(0.06, 0.11)	<0.001	0.02	(0.01, 0.03)	<0.001
Confusion - yes	2.05	(1.07, 3.91)	0.03	2.30	(1.01, 5.22)	0.047
Urea (by two-fold increase)	1.59	(1.05, 2.41)	0.03	1.51	(0.85, 2.70)	0.16
Respiratory rate (by +10 breaths/minute)	1.38	(1.10, 1.74)	0.01	1.23	(0.88,1.72)	0.23
Systolic blood pressure (by +10 mmHg)	0.90	(0.82, 0.98)	0.02	0.90	(0.79, 1.03)	0.11
Age (by +10 years)	0.82	(0.71, 0.95)	0.01	1.62	(1.18, 2.23)	0.003
ProADM* (by 2-fold increase)	1.92	(1.44, 2.57)	<0.001	1.84	(1.18, 2.87)	0.01

OR, Odds ratio, CI, Confidence interval.
Intercept corresponds to a person without confusion, urea of 7 mmol/l, respiratory rate of 20 breaths/minute, systolic blood pressure of 130 mmHg, age 70 years and ProADM of 1 nmol/l.
* OR (95% CI, P-value) for proADM in the complete case analysis without imputation of missing data are 1.61 (1.13 to 2.31; P = 0.01) for the prediction of serious complications and 1.65 (0.97 to 2.79; P = 0.06) for the prediction of death.

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