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Table 1 Characteristics of CAP patients at admission (n = 925)

From: Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections

Characteristics All CAP patients
(n = 925)
Serious complications (n = 134) No serious complications
(n = 791)
P AUC
Demographic characteristics      
-Age (years)* 72 (59 to 82) 74 (62 to 82) 72 (58 to 82) 0.33 0.53
- Sex (male) - no. (%) 544 (58.8) 87 (64.9) 457 (57.8) 0.12  
Coexisting illnesses - no. (%)      
-Coronary heart disease 183 (19.8) 38(28.4) 145 (18.3) 0.007 -
-Renal dysfunction 206 (22.3) 58 (43.3) 148 (18.7) <0.001 -
-COPD 282 (30.5) 58 (43.3) 224(28.3) 0.001 -
Clinical findings      
-Confusion - no. (%) 87 (9.4) 19 (14.2) 68 (8.6) 0.04 -
-Respiratory rate (breaths/minute)* 20 (16 to 25) 24 (18 to 30) 20 (16 to 25) <0.001 0.63
-Systolic blood pressure (mmHg)* 132 (119 to 148) 120 (105 to 140) 134 (120 to 150) <0.001 0.62
-Heart rate (beats/minute)* 95 (82 to 108) 99 (81 to 114) 94/102 to 106) 0.02 0.56
-Body temperature (C°)* 38.1 (37.2 to 38.9) 38.0 (37.1 to 38.7) 38.1 (37.3 to 38.9) 0.19 0.53
Biomarkers      
-Procalcitonin (μg/l)* 0.71 (0.44 to 1.53) 1.12 (0.66 to 2.39) 0.66 (0.43 to 1.41) <0.001 0.66
-ProADM (nmol/l)* 1.1 (0.9 to 1.3) 1.4 (1.1 to 1.8) 1.1 (0.9 to 1.3) <0.001 0.72
-ProANP (pmol/l)* 9.1 (7.1 to 12.1) 11.2 (8.2 to 14.4) 8.7 (6.7 to 11.7) <0.001 0.65
-ProET1 (pmol/l)* 7.8 (6.7 to 9.3) 9.6 (7.6 to 11.3) 7.6 (6.6 to 8.9) <0.001 0.72
-Copeptin (pmol/l)* 4.0 (3.0 to 5.5) 5.4 (4.0 to 8.2) 3.8 (2.9 to 5.2) <0.001 0.70
Risk assessment at admission      
-PSI points* 94 (67 to 116) 116 (95 to 141) 91/67 to 116) <0.001 0.69
-PSI class* 4 (2 to 4) 4 (4 to 5) 4 (2 to 4) <0.001 0.67
-CURB-65 points* 2 (1 to 2) 2 (1 to 3) 2 (1 to 2) <0.001 0.66
  1. Baseline characteristics based on first imputed dataset. P-values according to Wilcoxon rank sum test or chi-square test, respectively. AUCs correspond to averaged results over all imputed datasets and were calculated for continuous characteristics only.
  2. CAP, community-acquired pneumonia; PSI, pneumonia severity index; CURB65, confusion, uremia, respiratory rate, blood pressure, age 65 years or greater; AUC, area under the ROC curve; *expressed as median (interquartile range, IQR).