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Table 1 Basic data of CPR and CAD patients

From: Severe endothelial injury and subsequent repair in patients after successful cardiopulmonary resuscitation

  

CPR group

CAD group

P value

Group

 

CEC + EMP

EPC

All

CEC + EMP

EPC

All

 

Number of patients

 

n = 40

n = 15

n = 55

n = 30

n = 9

n = 39

 

Age

(years)

65.3 ± 2.2

66.8 ± 3.1

65.7 ± 1.8

64.9 ± 2.8

67 ± 4.3

64.3 ± 2.3

0.32/ns

Gender

Male

32 (80%)

10 (67%)

42 (76%)

26 (87%)

6 (67%)

32 (82%)

0.63/ns

 

Female

8 (20%)

5 (33%)

13 (24%)

4 (13%)

3 (33%)

7 (18%)

 

Location of CPR

in-hospital

13 (33%)

2 (13%)

15 (27%)

    
 

out-of-hospital

27 (67%)

13 (87%)

40 (73%)

    

Duration of CPR

(min)

27.3 ± 3.5

12.3 ± 2

23.2 ± 2.7

    

Initial rhythm

VF/VT

21 (52%)

11 (73%)

32 (58%)

    
 

Asystole/PEA

19 (48%)

4 (27%)

23 (42%)

    

Cause of cardiac arrest or hospital admission

Cardiac

29 (72%)

13 (87%)

42 (76%)

30 (100%)

8 (89%)

38 (97%)

0.11/ns

 

Non-cardiac

11 (28%)

3 (20%)

14 (24%)

0 (0%)

1 (11%)

1 (3%)

 

Coronary angiography

 

27 (68%)

14 (93%)

41 (75%)

21 (70%)

6 (66%)

27 (69%)

0.62/ns

Outcome

Survival <10 days

21 (52%)

5 (33%)

26 (47%)

0 (0%)

0 (0%)

0 (0%)

 
 

Survival ≥ 10 days

19 (48%)

10 (67%)

29 (53%)

30 (100%)

9 (100%)

39 (100%)

 

Medication

Vasopressors

32 (80%)

15 (100%)

47 (85%)

0 (0%)

0 (0%)

0 (0%)

 
 

Statins

14 (35%)

1 (7%)

15 (27%)

20 (67%)

3 (33%)

23 (59%)

<0.05

Consecutive organ failure

Acute heart failure

10 (25%)

3 (20%)

13 (24%)

0 (0%)

0 (0%)

0 (0%)

 
 

Acute renal failure

9 (23%)

1 (7%)

10 (18%)

0 (0%)

0 (0%)

0 (0%)

 
 

Acute liver failure

2 (1%)

0 (0%)

2 (4%)

0 (0%)

0 (0%)

0 (0%)

 

Co-morbidities

CAD

26 (65%)

14 (93%)

40 (73%)

30 (100%)

7 (77%)

37 (95%)

0.09/ns

 

PAD

6 (15%)

5 (33%)

11 (20%)

10 (33%)

1 (11%)

11 (28%)

0.25/ns

 

Congestive heart failure

6 (15%)

1 (7%)

7 (13%)

6 (20%)

3 (33%)

9 (23%)

0.10/ns

 

Pulmonary disease

12 (30%)

3 (20%)

15 (27%)

6 (20%)

4 (44%)

10 (26%)

0.89/ns

 

Renal insufficiency

20 (50%)

6 (40%)

26 (47%)

8 (27%)

4 (44%)

12 (31%)

0.07/ns

 

Liver insufficiency

7 (18%)

1 (7%)

8 (15%)

3 (10%)

0 (0%)

3 (8%)

0.14/ns

Cardiovascular risk factors

Hypertension

22 (55%)

4 (27%)

26 (47%)

17 (57%)

4 (44%)

21 (54%)

0.49/ns

 

Diabetes

11 (28%)

5 (33%)

16 (29%)

3 (10%)

1 (11%)

4 (10%)

<0.05

 

Hyperlipidemia

8 (20%)

1 (7%)

9 (16%)

15 (50%)

2 (22%)

17 (44%)

<0.01

 

Smoking

8 (20%)

5 (33%)

13 (24%)

10 (33%)

4 (44%)

14 (36%)

0.12/ns

  1. Basic data of the resuscitation group, including initial rhythm, outcome, location, and duration of CPR, and comparison of clinical variables in the CPR and CAD group. Both groups are comparable in baseline variables including age, gender, probable cause of cardiac arrest/cause of hospital admission, incidence of CAD, coronary angiography, congestive heart failure, and other relevant secondary disorders. There are slight but significant differences in distribution of cardiovascular risk factors as well as co-medication with statins.
  2. CAD, coronary artery disease; CEC, circulating endothelial cells; CPR, cardiopulmonary resuscitation; EMP, endothelial microparticles; EPC, endothelial progenitor cells; ns, not significant; PAD, peripheral artery disease; PEA, pulseless electrical activity; VF, ventricular fibrillation; VT, ventricular tachycardia.