Table 1 Summary of trials of erythropoietin in acutely critically ill patients
Year | Reference | n total | n sepsis | Enrolment | Dose | Duration |
|---|---|---|---|---|---|---|
1995 | Still and colleagues [96] | 40 | 0 | > 3 days | 150 IU/kg three times/week | 30 days |
1998 | Gabriel and colleagues [93] | 21 | ns | ICU admission | 600 IU/kg three times/week | Maximum 3 weeks |
1999 | Corwin and colleagues [92] | 80 | 6 | Day 3 | 300 IU/kg daily for 5 days | Maximum 6 weeks |
2000 | van Iperen and colleagues [97] | 36 | 23 | Hb < 11.2 g/dl | 300 IU/kg alternate days for 5 days | 5 doses |
2002 | Corwin and colleagues [87] | 1,352 | 105 | Day 3 | 40,000 IU/week | Maximum 3 weeks |
2005 | Georgopoulos and colleagues [94] | 148 | ns | Hb < 12.0 g/dl | 40,000 IU/week | Maximum 3 weeks |
2006 | Vincent and colleagues [84] | 68 | 14 | HCT < 0.38 | 40,000 IU/week | Maximum 4 weeks |
2006 | Silver and colleagues [95] | 86 | 25 | < 7 days | 40,000 IU/week | Maximum 12 weeks |
2007 | Corwin and colleagues [88] | 1,460 | 188 | Day 3/4 | 40,000 U/week | Maximum 3 weeks |