Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts

Table 2 Association between septic complications and genotype in 375 patients of Group I

Genotype	Severe Infections (n = 102)	^aOR	95% CI	P value
Wild-type (n = 240)	64 (26.7%)	0.87	0.51 - 1.48	0.69
Mutant alleles
*TLR4* (n = 41)	10 (24. 4%)	1.57	0.73 to 3.37	0.33
*TIRAP* (het) (n = 75)	15 (20.0%)	0.87	0.49 to 1.56	0.65
*TIRAP* (hom) (n = 10)	7 (70.0%)	7.33	1.89 to 28.50	< 0.01
*TIRAP/TLR4* genotype (n = 9)	6 (66.7%)	5.50	1.34 to 22.64	0.02

^aOR (odds ratio) when comparing severe infections (severe sepsis and septic shock) to patients with no infection. Calculated by comparison of wild type-patients with patients bearing other variants through Mantel-Haenzel's statistic and Fisher's exact test.
CI, confidence interval, het, heterozygous, hom, homozygous, Mal, MyD88-adaptor-like, MyD88, myeloid differentiation response factor 88, OR, odds ratio, TIR, toll/interleukin-1 receptor, TIRAP, TIR-associated protein, TLR, toll-like receptor.

ISSN: 1364-8535