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Table 2 Patient baseline characteristics

From: Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry

 

VASOPRESSOR-YES

(N = 7,160)

VASOPRESSOR-NO

(N = 1,808)

TOTAL

(N = 8,968)

 

LDC

(N = 2,794)

Non-LDC

(N = 4,366)

P -value

LDC

(N = 257)

Non-LDC

(N = 1,551)

P -value

LDC

(N = 3,051)

Non-LDC

(N = 5,917)

P -value

Age, mean (SD)

62.8 (16.3)

60.5 (17.9)

<0.001

59.1 (19.0)

56.6 (19.2)

0.049

62.4 (16.6)

59.5 (18.3)

<0.001

Region, n (%)

         

   Europe

1,067 (38.2)

878 (20.1)

<0.001

49 (19.1)

190 (12.3)

<0.001

1,116 (36.6)

1,068 (18.0)

<0.001

   Latin America

992 (35.5)

1,174 (26.9)

<0.001

71 (27.6)

632 (40.7)

<0.001

1,063 (34.8)

1,806 (30.5)

<0.001

   Northern America

112 (4.0)

285 (6.5)

<0.001

27 (10.5)

99 (6.4)

<0.001

139 (4.6)

384 (6.5)

<0.001

   Oceania

150 (5.4)

429 (9.8)

<0.001

6 (2.3)

98 (6.3)

<0.001

156 (5.1)

527 (8.9)

<0.001

   Asia

450 (16.1)

1,486 (34.0)

<0.001

99 (38.5)

512 (33.0)

<0.001

549 (18.0)

1,998 (33.8)

<0.001

   Other Regions

23 (0.8)

114 (2.6)

<0.001

5 (1.9)

20 (1.3)

<0.001

28 (0.9)

134 (2.3)

<0.001

Surgical, n (%)

1,309 (46.9)

1,795 (41.1)

<0.001

64 (24.9)

535 (34.5)

0.002

1,373 (45.0)

2,330 (39.4)

<0.001

Cardiovascular, n (%)

2,579 (92.3)

3,828 (87.7)

<0.001

49 (19.1)

333 (21.5)

0.346

2,628 (86.1)

4,161 (70.3)

<0.001

Respiratory, n (%)

2,445 (87.5)

3,587 (82.2)

<0.001

225 (87.5)

1,192 (76.9)

<0.001

2,670 (87.5)

4,779 (80.8)

<0.001

Hematology, n (%)

1,086 (38.9)

1,468 (33.6)

<0.001

94 (36.6)

389 (25.1)

<0.001

1,180 (38.7)

1,857 (31.4)

<0.001

Renal, n (%)

1,568 (56.1)

1,981 (45.4)

<0.001

68 (26.5)

487 (31.4)

0.098

1,636 (53.6)

2,468 (41.7)

<0.001

Hepatic, n (%)

675 (24.2)

893 (20.5)

0.001

35 (13.6)

232 (15.0)

0.512

710 (23.3)

1125 (19.0)

<0.001

Metabolic, n (%)

1,477 (52.9)

1,923 (44.0)

<0.001

95 (37.0)

452 (29.1)

0.023

1,572 (51.5)

2,375 (40.1)

<0.001

CNS, n (%)

1,138 (40.7)

1,417 (32.5)

<0.001

86 (33.5)

502 (32.4)

0.952

1,224 (40.1)

1,919 (32.4)

<0.001

Number of OD, mean (SD)*

4.0 (1.5)

3.5 (1.5)

<0.001

2.6 (1.4)

2.3 (1.3)

0.001

3.9 (1.6)

3.2 (1.5)

<0.001

SOFA, mean (SD)

10.4 (3.6)

9.7 (3.6)

<0.001

6.1 (2.8)

5.2 (3.0)

0.013

10.1 (3.7)

8.6 (4.0)

<0.001

APACHE II, Mean (SD)

25.2 (8.0)

23.1 (8.2)

<0.001

18.8 (6.7)

19.1 (7.0)

0.688

24.7 (8.1)

22.1 (8.1)

<0.001

Chronic Lung Disease, n (%)

486 (17.4)

541 (12.4)

<0.001

73 (28.4)

199 (12.8)

<0.001

559 (18.3)

740 (12.5)

<0.001

Active Cancer, n (%)

499 (17.9)

649 (14.9)

<0.001

33 (12.8)

174 (11.2)

0.455

532 (17.4)

823 (13.9)

<0.001

Other Chronic Disabling Condition, n (%)

725 (25.9)

857 (19.6)

<0.001

56 (21.8)

316 (20.4)

0.660

781 (25.6)

1173 (19.8)

<0.001

Fungal Infection, n (%)

352 (12.6)

346 (7.9)

<0.001

14 (5.4)

87 (5.6)

0.735

366 (12.0)

433 (7.3)

<0.001

  1. * Patients with missing data on one or more organs were excluded from the organ dysfunction summary.
  2. P-values are from a chi-square test for categorical variables, and from a non-parametric ANOVA test for continuous variables.
  3. LDC = Low-dose Corticosteroids, SD = Standard Deviation, CNS = Central Nervous System, OD = Organ Dysfunction, SOFA = Sequential Organ Failure Assessment, APACHE = Acute Physiology and Chronic Health Evaluation.
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