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Table 1 Demographic, clinical, and laboratory characteristics of study patients by disease presentation

From: The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children

  Meningitis Pneumonia P value
No. of patients 211 82  
Age in years (median, IQR) 2.3 (0.6-6.0) 2.7 (0.9-5.6) NS
Gender (male) (%) 116 (55%) 52 (63%) NS
SBI (%) 176 (83%) 40 (49%) 0.0005
Gram-positive infection (%)a 146 (69%) 36 (44%) NS
Gram-negative infection (%)a 29 (14%) 4 (5%) NS
Blantyre Coma Score ≤2 (%) 88 (42%) 1 (1%) 0.0005
HIV infected (%) 105 (50%) 49 (60%) NS
Duration of symptoms in days (median, IQR) 3 (2-4) 3 (3-6) 0.001
Inpatient mortality (%) 58 (28%) 6 (7%) 0.0005
Wasting (weight-for-height Z score ≤3 SD) 33/172 (19%) 7/69 (10%) NS
Stunting (height-for-age Z score ≤3 SD) 31/206 (15%) 16/79 (20%) NS
White cell count (×109/L) (median, IQR) 11.8 (7.3-19.2) 15.7 (9.9-25.3) 0.001
C-reactive protein (mg/L) (median, IQR) 258 (162-323) 275 (56-345) NS
Glucose (mmol/L) (median, IQR) 6.1 (4.8-7.6) 5.2 (4.4-6.0) 0.0005
Lactate (mmol/L) (median, IQR) 3.9 (2.4-6.3) 2.6 (1.8-5.2) 0.006
Systolic BP(mm Hg) (median, IQR) 103 (93-115) 100 (89-110) NS
Diastolic BP(mm Hg) (median, IQR) 66 (59-80) 66 (59-76) NS
  1. aOne child had mixed salmonella and pneumococcal infection (that is, mixed gram-positive and gram-negative infections). NS, not significant; P > 0.05.