Table 1 Demographic, clinical, and laboratory characteristics of study patients by disease presentation
| Â | Meningitis | Pneumonia | P value |
|---|---|---|---|
No. of patients | 211 | 82 | Â |
Age in years (median, IQR) | 2.3 (0.6-6.0) | 2.7 (0.9-5.6) | NS |
Gender (male) (%) | 116 (55%) | 52 (63%) | NS |
SBI (%) | 176 (83%) | 40 (49%) | 0.0005 |
Gram-positive infection (%)a | 146 (69%) | 36 (44%) | NS |
Gram-negative infection (%)a | 29 (14%) | 4 (5%) | NS |
Blantyre Coma Score ≤2 (%) | 88 (42%) | 1 (1%) | 0.0005 |
HIV infected (%) | 105 (50%) | 49 (60%) | NS |
Duration of symptoms in days (median, IQR) | 3 (2-4) | 3 (3-6) | 0.001 |
Inpatient mortality (%) | 58 (28%) | 6 (7%) | 0.0005 |
Wasting (weight-for-height Z score ≤3 SD) | 33/172 (19%) | 7/69 (10%) | NS |
Stunting (height-for-age Z score ≤3 SD) | 31/206 (15%) | 16/79 (20%) | NS |
White cell count (×109/L) (median, IQR) | 11.8 (7.3-19.2) | 15.7 (9.9-25.3) | 0.001 |
C-reactive protein (mg/L) (median, IQR) | 258 (162-323) | 275 (56-345) | NS |
Glucose (mmol/L) (median, IQR) | 6.1 (4.8-7.6) | 5.2 (4.4-6.0) | 0.0005 |
Lactate (mmol/L) (median, IQR) | 3.9 (2.4-6.3) | 2.6 (1.8-5.2) | 0.006 |
Systolic BP(mm Hg) (median, IQR) | 103 (93-115) | 100 (89-110) | NS |
Diastolic BP(mm Hg) (median, IQR) | 66 (59-80) | 66 (59-76) | NS |