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Table 2 Baseline measurements according to disease category

From: Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity

  Severe sepsis Sepsis without organ failure Control P value across all groups
N 52 31 41  
Angiopoietin 2 (ng/ml) a 12.44 (8.47-33.44) 6.11 (4.59-10.37) 2.71 (2.15-3.61) 0.0001d
VEGF (pg/ml) a 98.4 (56.4-142.6) 80.8 (57.5-147.3) 52.3 (31.8-73.5) 0.0007d
Plasma ICAM-1 (ng/ml) a 846 (523-1483) 501 (368-672) 323 (265-393) 0.0001d
Plasma E-selectin (ng/ml) a 200.5 (113-478) 87.0 (50.8-164.4) 38.4 (26.9-58.2) 0.0001d
RH-PAT index b 1.57 (1.44-1.71) 1.85 (1.67-2.03) 2.07 (1.93-2.22) <0.0001e
Plasma interleukin 6 (pg/ml) a 385.1 (124.2-996.0) 148.3 (45.9-315.0) 5.0 (2.2-8.1) 0.0001d
Plasma TNFα ≥ 2.8 pg/ml (n,%) c 8 (22) 4 (14) 5 (17) NSf
  1. a. Median (Interquartile range).
  2. b. Mean (95% confidence interval).
  3. c. 2.8 pg/ml is the lower limit of detection for the assay used for TNFα.
  4. d. By Kruskal-Wallis test.
  5. e. By oneway analysis of variance.
  6. f. By Fisher's exact test across all three groups.
  7. ICAM-1, intra-cellular adhesion molecule-1; NS, not significant; RH-PAT, reactive hyperemia peripheral arterial tonometry; TNFα, tumor necrosis factor α; VEGF, vascular endothelial growth factor.