Contextual fear response following LPS administration. Thirty minutes after undergoing contextual fear conditioning mice received LPS injection. Three and seven days later rodents were exposed to the same context in which fear conditioning was previously carried out. Contextual fear response reveals a clear hippocampal-dependent memory impairment both at day 3 and 7 (** P < 0.005 vs naive). Data are expressed as mean ± standard error of the mean (n = 6 for acute behavior) and compared by one-way analysis of variance and Student-Newman-Keuls method.