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Table 3 Association of urinary cystatin C with sepsis, acute kidney injury, and mortality

From: Urinary cystatin C is diagnostic of acute kidney injury and sepsis, and predicts mortality in the intensive care unit

  Sepsis AKI Mortality
Unadjusted AUC (95% CI) 0.80 (0.74 to 0.87) 0.70 (0.64 to 0.75) 0.64 (0.56 to 0.72)
Optimal cut point (mg/L) 0.24 0.12 0.09
Sensitivity (95% CI) 0.76 (0.65 to 0.84) 0.67 (0.58 to 0.75) 0.71 (0.66 to 0.76)
Specificity (95% CI) 0.76 (0.70 to 0.80) 0.64 (0.58 to 0.70) 0.53 (0.39 to 0.65)
Positive predictive value (95% CI) 0.41 (0.33 to 0.48) 0.42 (0.35 to 0.49) 0.20 (0.15 to 0.27)
Negative predictive value (95% CI) 0.93 (0.90 to 0.96) 0.83 (0.78 to 0.88) 0.92 (0.87 to 0.94)
Adjusted odds ratios (95% CI)    
For a 10-fold greater concentration 3.43 (2.46 to 4.78)a 1.49 (1.14 to 1.95)b 1.60 (1.16 to 2.21)c
>Optimal cut point 8.61 (4.65 to 16.0)a 2.45 (1.43 to 4.20)b 2.56 (1.38 to 4.78)c
>Above-normal cut point (0.1 mg/L) 4.98 (2.56 to 9.69)a 2.35 (1.36 to 4.05)b 2.28 (1.24 to 4.19)c
Logistic regression model AUC (95% CI) 0.84 (0.78 to 0.90)a 0.84 (0.79 to 0.89)b 0.68 (0.60 to 0.75)c
  1. aAdjusted for plasma cystatin C (pCysC), urinary creatinine (uCr), gender, hypotension, and APACHE II subcategory scores: respiratory rate, rectal temperature.
  2. bAdjusted for pCysC, uCr, age, hypotension, APACHE II subcategory scores: respiratory rate, white blood cell (WBC) count, arterial pH.
  3. cAdjusted for pCysC, age, gender, sepsis, and AKI.