Dead within 30 d (n = 64) | Alive at 30 d (n = 380) | P | Sepsis and AKI (n = 30) | Not sepsis and not AKI (n = 268) | P | |
---|---|---|---|---|---|---|
Age, years | 64 ± 17 | 58 ± 18 | 0.16 | 58 ± 18 | 59 ± 18 | 0.76 |
Female | 31 (48%) | 141 (37%) | 0.09 | 12 (40%) | 101 (38%) | 0.81 |
Baseline pCr, mmol/L | 0.08 (0.06-0.10) | 0.08 (0.06-0.09) | 0.13 | 0.07 (0.06-0.09) | 0.08 (0.06-0.09) | 0.32 |
Total APACHE II score | 22 ± 6.9 | 17 ± 5.9 | <0.0001 | 18.5 ± 7.1 | 17.1 ± 6.3 | 0.25 |
Heart Rate APACHE IIa <70 or >109 beats/minute | 54 (84%) | 272 (72%) | 0.32 | 24 (80%) | 196 (73%) | 0.42 |
Respiratory rate APACHE IIa <12 or >24 breaths/minute | 23 (36%) | 184 (48%) | 0.06 | 16 (53%) | 124 (46%) | 0.46 |
WBC APACHE IIa <3,000 or >14,900/mm3 | 32 (50%) | 177 (47%) | 0.61 | 16 (53%) | 109 (41%) | 0.18 |
Rectal temperature APACHE IIa <36.0°C or >38.4°C | 38 (59%) | 219 (58%) | 0.80 | 12 (40%) | 166 (62%) | 0.032 |
Arterial pH Apache IIa <7.33 or >7.49 | 52 (81%) | 254 (67%) | 0.02 | 22 (73%) | 173 (65%) | 0.34 |
Hypotension before the ICU | 32 (50%) | 178 (47%) | 0.64 | 14 (47%) | 121 (45%) | 0.88 |
Vasopressor/Catecholamine use | 43 (67%) | 240 (63%) | 0.38 | 22 (73.3) | 175 (65%) | 0.38 |
Urine output (first 6 hours), mL | 395 (209-785) | 560 (331-910) | 0.01 | 382 (229-546) | 626 (358-1,020) | 0.001 |
Mechanical ventilationb | 59 (92%) | 335 (88%) | 0.35 | 22 (73%) | 240 (90%) | 0.006 |
Length of mechanical ventilation,b days | 3.5 ± 2.3 | 2.8 ± 2.5 | 0.06 | 3.6 ± 3.0 | 2.6 ± 2.3 | 0.019 |
uCysC, mg/L | 0.32 (0.08-2.21) | 0.08 (0.04-0.68) | 0.0004 | 5.48 (0.85-13.05) | 0.06 (0.02-0.15) | <0.0001 |
uCr, mmol/L | 6.10 (2.55-9.57) | 5.3 (2.43-9.947) | 0.94 | 8.85 (5.30-13.13) | 4.05 (1.90-7.80) | <0.0001 |
pCr, mmol/L | 0.09 (0.07-0.13) | 0.09 (0.07-0.12) | 0.64 | 0.15 (0.10-0.18) | 0.08 (0.07-0.10) | <0.0001 |
pCysC, mg/L | 1.0 (0.76-1.44) | 0.83 (0.65-1.18) | 0.01 | 1.32 (0.93-1.90) | 0.74 (0.61-1.00) | <0.0001 |
Length of ICU stay, hours | 100 (54-162) | 70 (42-183) | 0.37 | 112 (58-334) | 62 (10-144) | 0.004 |
Dead within 30 days | 64 (100%) | 0 | 4 (13%) | 32 (12%) | 0.83 | |
AKI | 24 (38%) | 101(27%) | 0.07 | 30 (100%) | 0 | |
Sepsis | 12 (19%) | 69 (18%) | 0.9 | 30 (100%) | 0 |