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Table 4 Odds ratio for 28-days mortality for each action of the bundle completed in patients with septic shock

From: Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study)

  Odds ratio SIMPLE (95% CI) P value Odds ratio ADJUSTED (95% CI) P value
Individual actions of the bundle     
   1) Serum lactate measured in the first 6-hours 0.68 (0.46; 1.02) 0.064 0.64 (0.40; 1.03) 0.064
   2) Fluids administered to achieve a MAP >65 mmHg 0.82 (0.52; 1.28) 0.383 1.01 (0.60; 1.70) 0.984
   3) Specimens collected for microbiology before antibiotic started 0.61 (0.37; 0.98) 0.041 0.57 (0.33; 0.97) 0.037
   4) Blood cultures done 0.52 (0.32; 0.84) 0.008 0.50 (0.29; 0.88) 0.016
   5) Antibiotic therapy administered in the first hour after diagnosis 0.83 (0.56; 1.23) 0.356 0.77 (0.49; 1.21) 0.258
   6) Vasopressores administered to achieve a MAP >65 mmHg 0.54 (0.30; 0.97) 0.038 0.52 (0.28; 0.99) 0.048
   7) Was CVP measured? 0.62 (0.41; 0.94) 0.023 0.74 (0.47; 1.18) 0.207
   8) SvcO2 measured? 0.85 (0.50; 1.46) 0.853 0.76 (0.40; 1.44) 0.396
   9) Inotropes administered 0.98 (0.56; 1.70) 0.931 0.94 (0.49; 1.80) 0.848
Bundle     
   Bundle completed with actions 1) through 6) versus partial or non completed 0.51
(0.29; 0.90)
0.021 0.49
(0.25; 0.95)
0.036
   Bundle completed with the 9 actions versus partial or non completed 0.51
(0.21; 1.26)
0.146 0.41
(0.14; 1.19)
0.101
  1. The odds ratio is presented for each variable as single and grouped and it is adjusted for SAPS II, number of comorbidities, type of hospital and type of ICU for patients with septic shock. These results are based on 437 patients with septic shock. CI: confidence interval; CVP: central venous pressure; MAP: mean arterial pressure; SAPS: Simplified Acute Physiological Score; SvcO2: central venous oxygen saturation.