Table 4 Odds ratio for 28-days mortality for each action of the bundle completed in patients with septic shock
Odds ratio SIMPLE (95% CI) | P value | Odds ratio ADJUSTED (95% CI) | P value | |
|---|---|---|---|---|
Individual actions of the bundle | ||||
1) Serum lactate measured in the first 6-hours | 0.68 (0.46; 1.02) | 0.064 | 0.64 (0.40; 1.03) | 0.064 |
2) Fluids administered to achieve a MAP >65 mmHg | 0.82 (0.52; 1.28) | 0.383 | 1.01 (0.60; 1.70) | 0.984 |
3) Specimens collected for microbiology before antibiotic started | 0.61 (0.37; 0.98) | 0.041 | 0.57 (0.33; 0.97) | 0.037 |
4) Blood cultures done | 0.52 (0.32; 0.84) | 0.008 | 0.50 (0.29; 0.88) | 0.016 |
5) Antibiotic therapy administered in the first hour after diagnosis | 0.83 (0.56; 1.23) | 0.356 | 0.77 (0.49; 1.21) | 0.258 |
6) Vasopressores administered to achieve a MAP >65 mmHg | 0.54 (0.30; 0.97) | 0.038 | 0.52 (0.28; 0.99) | 0.048 |
7) Was CVP measured? | 0.62 (0.41; 0.94) | 0.023 | 0.74 (0.47; 1.18) | 0.207 |
8) SvcO2 measured? | 0.85 (0.50; 1.46) | 0.853 | 0.76 (0.40; 1.44) | 0.396 |
9) Inotropes administered | 0.98 (0.56; 1.70) | 0.931 | 0.94 (0.49; 1.80) | 0.848 |
Bundle | ||||
Bundle completed with actions 1) through 6) versus partial or non completed | 0.51 (0.29; 0.90) | 0.021 | 0.49 (0.25; 0.95) | 0.036 |
Bundle completed with the 9 actions versus partial or non completed | 0.51 (0.21; 1.26) | 0.146 | 0.41 (0.14; 1.19) | 0.101 |