Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study)

Table 3 Odds ratio for 28-days mortality for each action of the bundle completed in patients with severe sepsis

	Odds ratio SIMPLE (95% CI)	P value	Odds ratio ADJUSTED (95% CI)	P value
Individual actions of the core bundle
1) Serum lactate measured in the first six-hours	0.84 (0.61; 1.15)	0.272	0.74 (0.51; 1.06)	0.102
2) Fluids administered to achieve a MAP >65 mmHg	1.03 (0.73; 1.44)	0.870	0.95 (0.64; 1.41)	0.812
3) Specimens collected for microbiology before antibiotic therapy	0.80 (0.55; 1.15)	0.228	0.71 (0.47; 1.07)	0.101
4) Blood cultures done	0.57 (0.38; 0.84)	0.005	0.53 (0.34; 0.83)	0.005
5) Antibiotic therapy administered in the first hour after diagnosis	0.91 (0.67; 1.25)	0.561	0.85 (0.59; 1.21)	0.355
6) Vasopressors administered to achieve a MAP >65 mmHg	0.67 (0.42; 1.06)	0.089	0.51 (0.30; 0.88)	0.014
Actions, 1 to 6, completed
0 to 2	1.00		1.00
3 to 5	0.86 (0.62; 1.18)	0.601	0.73 (0.51; 1.05)	0.091
Fully completed	0.61 (0.36; 1.02)	0.061	0.44 (0.24; 0.80)	0.006

The odds ratio is presented for each action of the bundle as single and grouped and it is adjusted for severity of sepsis, SAPS II, number of comorbidities, type of hospital and type of ICU for patients with severe sepsis. These results are based on 778 patients with severe sepsis and septic shock on ICU admission. CI: confidence interval; MAP: mean arterial pressure; SAPS: Simplified Acute Physiological Score.

ISSN: 1364-8535