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Table 3 Distribution of PAI-1 4G/5G genotypes and alleles as stratified according to multiple organ dysfunction, sepsis severity and mortality

From: 4G/5G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis: prospective, observational, genetic study

  Multiple organ dysfunction Sepsis severity ICU mortality
  Non-MODS (n = 86) MODS
(n = 121)
p value* Severe sepsis
(n = 118)
Septic shock
(n = 89)
p value* Survivors
(n = 129)
Non-survivors (n = 78) p value*
Genotype          
4G/4G and 4G/5G 62 (72.1%) 106 (87.6%)   89 (75.4%) 79 (88.8%)   100 (77.5%) 68 (87.2%)  
5G/5G 24 (27.9%) 15 (12.4%) 0.005 29 (24.6%) 10 (11.2%) 0.015 29 (22.5%) 10 (12.8%) 0.085
Allele          
4G 86 (50.0%) 145 (59.9%)   120 (50.8%) 111 (62.4%)   136 (52.7%) 95 (60.9%)  
5G 86 (50.0%) 97 (40.1%) 0.045 116 (49.2%) 67 (37.6%) 0.019 122 (47.3%) 61 (39.1%) 0.104
  1. *Pearson Chi-square tests
  2. MODS, multiple organ dysfunction syndrome; PAI-1, plasminogen activator inhibitor 1.