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Table 1 Probabilities used in the decision analysis

From: Prophylactic anticoagulation to prevent venous thromboembolism in traumatic intracranial hemorrhage: a decision analysis

Variables Baseline probability Range of plausible probabilities Threshold value within published range Threshold from 0 to 1
Probability of DVT 0.32 [12] 0.18 to 0.50 [[9] to [11, 12]] No Yes (> 0.6*)
Probability of PE following development of DVT 0.1[42, 43] 0.01 to 0.18 [22, 24, 44, 45] No Yes (> 0.3*)
Probability of death from PE 0.17 [46] 0 to 0.50 [47] No No
Probability of a CNS bleed on LMWH 0.108 [15] 0.03 to 0.23 [24, 44] No Yes (> 0.017+)
Effectiveness of LMWH in preventing DVT (e) 0.47 [12] 0.33 to 0.82 [12, 42] Yes (> 0.8*) Yes (> 0.8*)
Probability of death from a CNS bleed 0.105 [48] 0.08 to 0.3 [49, 50] No No
Probability of disabling neurological deficit after CNS bleed 0.17 [51] 0.16 to 0.33 [52, 53] No No
Probability of an ICU-related systemic bleed 0.035 [23] 0.027 to 0.046 [23] No No
Probability of death from ICU-related systemic bleed 0.02 [23] 0.001 to 0.035 [23, 46] No No
Effectiveness of not receiving LMWH in reducing CNS bleeds 0.315 [4, 15] 0.001-0.99 [46, 23, 47, 54] Yes (> 0.05+) Yes (> 0.05+)
Effectiveness of not receiving LMWH in reducing ICU-related systemic bleeds 0.146 0 to 0.66 [8, 12, 55] No No
  1. Table of probabilities and plausible ranges used for the decision analysis. The last two columns indicate variables for which a threshold value was identified in one-way sensitivity analysis. Values with an asterisk (*) indicate a threshold value above which providing anticoagulant prophylaxis becomes the preferred strategy. Values with a plus (+) indicate a threshold value above which withholding anticoagulant prophylaxis becomes the preferred strategy.
  2. CNS: central nervous system; DVT: deep vein thrombosis; ICU: intensive care unit; PE: pulmonary embolism