Figure 4
From: Inhaled activated protein C protects mice from ventilator-induced lung injury
Inhaled APC preserves alveolo-capillary barrier function in VILI. BAL total protein concentration (top) increased in mice receiving saline (NS) and injurious ventilation (HVt) compared with a reference group of only briefly ventilated animals (LVt-30 min), indicating alveolo-capillary membrane dysfunction. Activated protein C (APC) reduced protein leak in the airspace. Changes in broncho-alveolar lavage (BAL) angiotensin-converting enzyme activity (bottom) were also reversed by APC (data expressed as mean ± standard deviation; * denotes P < 0.05 for comparison with LVt-30 min; One-way analysis of variance or Kruskal-Wallis test with post-hoc analysis by Dunnett's test). VILI, ventilator-induced lung injury.