Table 5 Characteristics of the patients
From: Febrile neutropenia in French emergency departments: results of a prospective multicentre survey
Total population | Patients with severe sepsis | Patients without severe sepsis | P | |
|---|---|---|---|---|
Number of patients | 198 | 89 | 108 | |
Age (years), mean ± SD | 61 ± 14 | 65 ± 13 | 57 ± 14 | <0.001 |
Female, n (%) | 79 (41) | 30 (34) | 49 (46) | 0.11 |
Karnofsky index, median (range) | 70 (30-100) | 70 (30-100) | 80 (30-100) | 0.06 |
Underlying disorders, n (%) | 73 (38) | 36 (43) | 37 (35) | 0.32 |
Chronic pulmonary disease | 9 (12) | 6 (16) | 3 (3) | |
Chronic heart failure | 12 (16) | 9 (24) | 3 (3) | |
Cirrhosis | 7 (9) | 4 (11) | 3 (3) | |
Hemodialysis chronic renal failure | 2 (3) | 2 (5) | 0 | |
Severe neurological disorder | 3 (4) | 1 (3) | 2 (2) | |
Other | 51 (69) | 21 (57) | 30 (29) | |
Haematological neoplasm, n (%) | 87 (44) | 40 (45) | 47 (44) | 0.84 |
Lymphoproliferation | 64 (32) | 30 (34) | 34 (31) | |
Myeloproliferation | 22 (11) | 10 (11) | 12 (11) | |
Undetermined | 1 | 0 | 1 | |
Solid cancer | 111 (56) | 49 (55) | 61 (56) | |
Lung | 39 (20) | 24 (27) | 15 (14) | |
Breast | 26 (13) | 9 (10) | 17 (16) | |
Urological and genital | 18 (9) | 9 (10) | 9 (8) | |
Gastro-intestinal | 13 (7) | 5 (6) | 7 (6) | |
Other or undetermined | 15 (8) | 1 | 8 (7) | |
Presence of metastasis or uncontrolled | 133 (67) | 69 (78) | 63 (58) | 0.004 |
Previous history of febrile neutropenia | 60 (31) | 24 (27) | 36 (35) | 0.32 |
Chemotherapy at high-risk for neutropenia | 36 (23) | 15 (21) | 21 (25) | 0.57 |
Corticosteroids | 83 (42) | 37 (42) | 46 (43) | 0.89 |
Prophylaxis with G-CSF | 47 (25) | 18 (20) | 29 (28) | 0.22 |
Antimicrobial therapy prior to ED | 48 (25) | 15 (17) | 33 (31) | 0.03 |
MASCC <20 (high-risk) | 105 (53) | 67 (75) | 38 (35) | <0.001 |