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Table 1 Pulmonary myeloperoxidase, cytokine and chemokine levels 48 and 96 hours after induction of lethal H1N1 influenza A infection

From: Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

  Placebo rm-APC placebo rm-APC
MPO (ng/ml) 5.0 (3.9 to 5.9) 4.9 (4.2 to 5.1) 6.4 (5.6 to 6.9) 6.8 (6.2 to 8.9)
TNF-α (pg/ml) 120 (97 to 134) 121 (101 to 143) 393 (293 to 495) 167 (139 to 344) *
IL-1β (pg/ml) 236 (100 to 415) 389 (331 to 389) 479 (444 to 549) 371 (345 to 587)
IL-6 (ng/ml) 0.9 (0.7 to 1.0) 0.8 (0.7 to 0.9) 1.3 (1.0 to 1.6) 1.0 (0.7 to 1.3)
IL-12 (pg/ml) B.D. B.D. 54 (37 to 64) 11 (5.0 to 28) *
IL-10 (pg/ml) 137 (86 to 165) 131 (101 to 153) 115 (82 to 175) 65 (23 to 147)
IFN-γ (pg/ml) 6.8 (6.0 to 9.7) 6.9 (5.8 to 7.9) 6.7 (4.9 to 8.1) 5.6 (3.5 to 7.9)
KC (ng/ml) 3.1 (2.3 to 3.7) 4.0 (2.9 to 5.1) 3.4 (2.6 to 4.4) 4.2 (3.3 to 5.6)
MIP-2 (ng/ml) 1.2 (0.8 to 1.4) 1.5 (1.2 to 1.6) 1.4 (1.3 to 1.5) 1.5 (1.4 to 1.7)
  1. Data are medians (interquartile ranges) of eight mice per group at each time point. * indicates statistical significance compared to placebo (P < 0.05). MPO, myeloperoxidase, TNF-α, tumor necrosis factor-α, IL, interleukin, IFN-γ, interferon-γ, KC, keratinocyte-derived chemokine, MIP-2, macrophage inflammatory protein-2, B.D., below detection.