Figure 3

Lung histopathology in lethal H1N1 influenza A infection is not influenced by recombinant murine activated protein C treatment. Representative slides of lung haematoxylin and eosin staining 96 hours after induction of lethal influenza A infection in A. buffer control treated mice and B. recombinant murine activated protein C treated mice (original magnification × 100). C. Total pathology score (described in methods section) 48 and 96 hours after induction of lethal influenza A infection in buffer control treated mice (white) and recombinant murine activated protein C treated mice (grey). Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (eight mice per group at each time point). No statistical differences between the groups at each time point.