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Figure 1 | Critical Care

Figure 1

From: Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

Figure 1

Activation of coagulation in lethal H1N1 influenza A infection is attenuated by recombinant murine activated protein C treatment. Levels of A. and C. thrombin-antithrombin complexes (TATc) and B. and D. fibrin degradation products (FDP) in A. and B. lung and C. and D. plasma at baseline (dashed) and 48 and 96 hours after induction of lethal influenza A infection in buffer control treated mice (white) and recombinant murine activated protein C treated mice (grey). Data are expressed as box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile and largest observation (eight mice per group at each time point). ## and ### indicate statistical significance as compared to baseline (P < 0.01 and P < 0.001 respectively, Mann-Whitney U test), ** and *** indicate statistical significance as compared to buffer control (P < 0.01 and P < 0.001 respectively, Mann-Whitney U test).

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Critical Care

ISSN: 1364-8535