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Table 2 Haemodynamic parameters (mean ± standard deviation). Parameters included in the table are heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary pressure (MPAP) and cardiac output (CO) at baseline (after splenectomy), after fibrinogen substitution (fibrinogen), haemodilution, five minutes after trauma and at the end of the observation period (trauma)

From: Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury

  Baseline Haemodilution Fibrinogen 5 min after Trauma Trauma
HR (beats min-1)      
   Control 83 ± 15 99 ± 11 99 ± 10 115 ± 12 155 ± 22
   F-70 86 ± 12 92 ± 13 84 ± 11 110 ± 10 146 ± 15
   F-200 87 ± 13 81 ± 18 82 ± 12 127 ± 14 175 ± 13
MAP (mmHg)      
   Control 79 ± 10 78 ± 6 75 ± 5 41 ± 4 13 ± 1
   F-70 75 ± 9 75 ± 8 76 ± 6 39 ± 3 29 ± 7*
   F-200 83 ± 11 77 ± 5 81 ± 5 45 ± 5 36 ± 4*
CVP (mmHg)      
   Control 8 ± 2 7 ± 2 7 ± 2 4 ± 1 1 ± 1
   F-70 8 ± 1 8 ± 2 8 ± 1 5 ± 1 4 ± 0.5*
   F-200 9 ± 2 8 ± 3 8 ± 1 5 ± 2 6 ± 1*
MPAP (mmHg)      
   Control 20 ± 1 20 ± 2 19 ± 3 14 ± 1 7 ± 2
   F-70 18 ± 2 20 ± 3 20 ± 3 13 ± 2 9 ± 1
   F-200 17 ± 2 18 ± 2 21 ± 3 12 ± 1 12 ± 2*
CO (L min-1)      
   Control 4.4 ± 0.5 4.0 ± 0.7 3.7 ± 0.7 2.5 ± 0.2 1.2 ± 0.5
   F-70 3.7 ± 0.7 3.4 ± 0.4 3.4 ± 0.5 2.6 ± 0.3 2.3 ± 0.4*
   F-200 4.5 ± 0.8 3.6 ± 0.9 3.6 ± 0.6 2.2 ± 0.2 2.5 ± 0.5*
  1. *P < 0.005 vs. control.