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Table 2 Haemodynamic parameters (mean ± standard deviation). Parameters included in the table are heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary pressure (MPAP) and cardiac output (CO) at baseline (after splenectomy), after fibrinogen substitution (fibrinogen), haemodilution, five minutes after trauma and at the end of the observation period (trauma)

From: Effects of different fibrinogen concentrations on blood loss and coagulation parameters in a pig model of coagulopathy with blunt liver injury

 

Baseline

Haemodilution

Fibrinogen

5 min after Trauma

Trauma

HR (beats min-1)

     

   Control

83 ± 15

99 ± 11

99 ± 10

115 ± 12

155 ± 22

   F-70

86 ± 12

92 ± 13

84 ± 11

110 ± 10

146 ± 15

   F-200

87 ± 13

81 ± 18

82 ± 12

127 ± 14

175 ± 13

MAP (mmHg)

     

   Control

79 ± 10

78 ± 6

75 ± 5

41 ± 4

13 ± 1

   F-70

75 ± 9

75 ± 8

76 ± 6

39 ± 3

29 ± 7*

   F-200

83 ± 11

77 ± 5

81 ± 5

45 ± 5

36 ± 4*

CVP (mmHg)

     

   Control

8 ± 2

7 ± 2

7 ± 2

4 ± 1

1 ± 1

   F-70

8 ± 1

8 ± 2

8 ± 1

5 ± 1

4 ± 0.5*

   F-200

9 ± 2

8 ± 3

8 ± 1

5 ± 2

6 ± 1*

MPAP (mmHg)

     

   Control

20 ± 1

20 ± 2

19 ± 3

14 ± 1

7 ± 2

   F-70

18 ± 2

20 ± 3

20 ± 3

13 ± 2

9 ± 1

   F-200

17 ± 2

18 ± 2

21 ± 3

12 ± 1

12 ± 2*

CO (L min-1)

     

   Control

4.4 ± 0.5

4.0 ± 0.7

3.7 ± 0.7

2.5 ± 0.2

1.2 ± 0.5

   F-70

3.7 ± 0.7

3.4 ± 0.4

3.4 ± 0.5

2.6 ± 0.3

2.3 ± 0.4*

   F-200

4.5 ± 0.8

3.6 ± 0.9

3.6 ± 0.6

2.2 ± 0.2

2.5 ± 0.5*

  1. *P < 0.005 vs. control.